Table 3—

Summary of all reported studies of D76N

StudyCase subjectsControl subjectsReference no.
Macfarlane et al., England 5 of 206 7 of 675 14 
Hani et al., France 9 of 192 1 of 231 13 
Reis et al., France 0 of 296 0 of 147 16 
Hansen et al., Denmark 1 of 200 — 15 
Weng et al., Botnia (Finland) 2 of 183 0 of 92 25 
Silver and Shetty., U.S., Caucasian 0 of 110 1 of 107 17 
Brittman et al., Italy 1 of 89 0 of 50 22 
Elbein and Karim., Utah, Caucasian 2 of 190 3 of 191 — 
Total 20 of 1,466 (1.36) 12 of 1,475 (0.81) — 
StudyCase subjectsControl subjectsReference no.
Macfarlane et al., England 5 of 206 7 of 675 14 
Hani et al., France 9 of 192 1 of 231 13 
Reis et al., France 0 of 296 0 of 147 16 
Hansen et al., Denmark 1 of 200 — 15 
Weng et al., Botnia (Finland) 2 of 183 0 of 92 25 
Silver and Shetty., U.S., Caucasian 0 of 110 1 of 107 17 
Brittman et al., Italy 1 of 89 0 of 50 22 
Elbein and Karim., Utah, Caucasian 2 of 190 3 of 191 — 
Total 20 of 1,466 (1.36) 12 of 1,475 (0.81) — 

Data show the number of individuals who carry the N allele in each study. The frequency (percentage) of heterozygous individuals for all combined studies is shown in parentheses for case and control subjects.

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