ORs for 10-year incidence of type 2 diabetes according to HOMA-IR score (insulin resistance) and Sluiter’s Index (β-cell secretion)
| . | Person-years . | Diabetes cases . | Incidence rate/1,000 person-years (95% CI) . | OR (95% CI) . | P value . |
|---|---|---|---|---|---|
| Baseline HOMA-IR score* | |||||
| Quartile 1† | 1,695 | 4 | 2.4 (0.1–4.7) | 1.0 | |
| Quartile 2 | 1,687 | 12 | 7.1 (3.1–11.1) | 2.9 (0.9–9.3) | 0.076 |
| Quartile 2 | 1,688 | 11 | 6.5 (2.7–10.3) | 2.5 (0.7–8.3) | 0.126 |
| Quartile 4 | 1,649 | 32 | 19.4 (12.7–26.1) | 8.5 (2.9–25.1) | <0.001 |
| Baseline Sluiter’s Index‡ | |||||
| Quartile 1 | 1,666 | 22 | 13.2 (7.7–18.7) | 3.0 (1.3–6.9) | 0.012 |
| Quartile 2 | 1,705 | 12 | 7.0 (3.0–11.0) | 1.5 (0.6–3.8) | 0.374 |
| Quartile 3 | 1,675 | 17 | 10.1 (5.3–14.9) | 2.3 (0.9–5.4) | 0.066 |
| Quartile 4† | 1,673 | 8 | 4.8 (1.5–8.1) | 1.0 |
| . | Person-years . | Diabetes cases . | Incidence rate/1,000 person-years (95% CI) . | OR (95% CI) . | P value . |
|---|---|---|---|---|---|
| Baseline HOMA-IR score* | |||||
| Quartile 1† | 1,695 | 4 | 2.4 (0.1–4.7) | 1.0 | |
| Quartile 2 | 1,687 | 12 | 7.1 (3.1–11.1) | 2.9 (0.9–9.3) | 0.076 |
| Quartile 2 | 1,688 | 11 | 6.5 (2.7–10.3) | 2.5 (0.7–8.3) | 0.126 |
| Quartile 4 | 1,649 | 32 | 19.4 (12.7–26.1) | 8.5 (2.9–25.1) | <0.001 |
| Baseline Sluiter’s Index‡ | |||||
| Quartile 1 | 1,666 | 22 | 13.2 (7.7–18.7) | 3.0 (1.3–6.9) | 0.012 |
| Quartile 2 | 1,705 | 12 | 7.0 (3.0–11.0) | 1.5 (0.6–3.8) | 0.374 |
| Quartile 3 | 1,675 | 17 | 10.1 (5.3–14.9) | 2.3 (0.9–5.4) | 0.066 |
| Quartile 4† | 1,673 | 8 | 4.8 (1.5–8.1) | 1.0 |
Unadjusted incidence rates are per 1,000 person-years. ORs and P values are derived from a logistic regression model adjusted for age and sex. The slightly lower number of cases with diabetes is due to missing serum for insulin measurements in a few subjects.
The overall P value is <0.001;
reference category;
overall P value = 0.008.