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TABLE 2

Metabolic parameters during hyperinsulinemic-euglycemic clamp periods in control (saline), IL-6–treated, IL-6–and IL-10–co-treated, lipid-infused, and lipid- and IL-10–co-treated groups

Clamp period
Plasma glucose (mmol/l)Plasma insulin (pmol/l)Glucose infusion rate (μmol · kg−1 · min−1)
Control 7.1 ± 0.2 409 ± 22 183 ± 11 
IL-6–treated 7.0 ± 0.7 432 ± 52 88 ± 12* 
IL-6–and IL-10–co-treated 7.1 ± 0.4 420 ± 16 191 ± 14 
Lipid-infused 6.4 ± 0.2 427 ± 56 140 ± 6* 
Lipid- and IL-10–co-treated 6.6 ± 0.4 442 ± 61 180 ± 17 
Clamp period
Plasma glucose (mmol/l)Plasma insulin (pmol/l)Glucose infusion rate (μmol · kg−1 · min−1)
Control 7.1 ± 0.2 409 ± 22 183 ± 11 
IL-6–treated 7.0 ± 0.7 432 ± 52 88 ± 12* 
IL-6–and IL-10–co-treated 7.1 ± 0.4 420 ± 16 191 ± 14 
Lipid-infused 6.4 ± 0.2 427 ± 56 140 ± 6* 
Lipid- and IL-10–co-treated 6.6 ± 0.4 442 ± 61 180 ± 17 

Data are means ± SE.

*

P < 0.05 vs. control mice by Duncan’s multiple range test.

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