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TABLE 1

Effect of the GABAA receptor antagonist SR95531 on hormone release from isolated rat islets

Glucose (mmol/l)Insulin (ng · islet−1 · h−1)
Somatostatin (pmol · islet−1 · h−1)
Glucagon (pg · islet−1 · h−1)
120120120
Control 0.37 ± 0.03 6.17 ± 0.3 5.05 ± 0.5 24.48 ± 1.1 27.18 ± 2.1 15.31 ± 1.2 
10 μmol/l SR95531 0.32 ± 0.06 6.01 ± 0.2 5.50 ± 0.2 26.1 ± 1.6 46.72 ± 3.8* 51.04 ± 4.0* 
Glucose (mmol/l)Insulin (ng · islet−1 · h−1)
Somatostatin (pmol · islet−1 · h−1)
Glucagon (pg · islet−1 · h−1)
120120120
Control 0.37 ± 0.03 6.17 ± 0.3 5.05 ± 0.5 24.48 ± 1.1 27.18 ± 2.1 15.31 ± 1.2 
10 μmol/l SR95531 0.32 ± 0.06 6.01 ± 0.2 5.50 ± 0.2 26.1 ± 1.6 46.72 ± 3.8* 51.04 ± 4.0* 

Data are means ± SE of 10 experiments.

*

P < 0.001 vs. control;

NS vs. 10 μmol/l SR95531 at 1 mmol/l glucose.

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