American Diabetes Association

TABLE 1

Effect of the GABA_A receptor antagonist SR95531 on hormone release from isolated rat islets

Glucose (mmol/l)	Insulin (ng · islet⁻¹ · h⁻¹)			Somatostatin (pmol · islet⁻¹ · h⁻¹)			Glucagon (pg · islet⁻¹ · h⁻¹)
Glucose (mmol/l)		1	20	1	20	1	20
Control	0.37 ± 0.03	6.17 ± 0.3	5.05 ± 0.5	24.48 ± 1.1	27.18 ± 2.1	15.31 ± 1.2
10 μmol/l SR95531	0.32 ± 0.06	6.01 ± 0.2	5.50 ± 0.2	26.1 ± 1.6	46.72 ± 3.8^*	51.04 ± 4.0^*^†

Glucose (mmol/l)	Insulin (ng · islet⁻¹ · h⁻¹)			Somatostatin (pmol · islet⁻¹ · h⁻¹)			Glucagon (pg · islet⁻¹ · h⁻¹)
Glucose (mmol/l)		1	20	1	20	1	20
Control	0.37 ± 0.03	6.17 ± 0.3	5.05 ± 0.5	24.48 ± 1.1	27.18 ± 2.1	15.31 ± 1.2
10 μmol/l SR95531	0.32 ± 0.06	6.01 ± 0.2	5.50 ± 0.2	26.1 ± 1.6	46.72 ± 3.8^*	51.04 ± 4.0^*^†

Data are means ± SE of 10 experiments.

P < 0.001 vs. control;

†

NS vs. 10 μmol/l SR95531 at 1 mmol/l glucose.