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TABLE 1

Effects of hypoxia on blood gases, ventilation, and systemic hemodynamics

Variable/conditionSaline
Phentolamine
ControlDiabetesControlDiabetes
Hb saturation (%)     
    Normoxia 97.1 ± 0.3 97.4 ± 0.3 97.6 ± 0.2 97.0 ± 0.3 
    Hypoxia 82.1 ± 1.3* 81.9 ± 1.2* 83.4 ± 1.3* 83.6 ± 1.5* 
PO2 (mmHg)     
    Normoxia 91.9 ± 4.5 91.8 ± 3.3 92.3 ± 3.5 90.9 ± 3.6 
    Hypoxia 43.7 ± 1.1* 43.9 ± 0.9* 43.7 ± 0.5* 44.9 ± 1.4* 
PETCO2(mmHg)     
    Normoxia 36.3 ± 0.9 35.4 ± 2.9 35.8 ± 1.4 37.0 ± 1.8 
    Hypoxia 36.2 ± 1.1 34.0 ± 2.9 35.1 ± 1.1 35.7 ± 1.7 
pH     
    Normoxia 7.42 ± 0.01 7.40 ± 0.01 7.42 ± 0.01 7.41 ± 0.01 
    Hypoxia 7.43 ± 0.01 7.44 ± 0.01* 7.44 ± 0.01* 7.45 ± 0.01 
Minute ventilation (l/min BTPS)     
    Normoxia 6.4 ± 1.2 6.4 ± 1.1 6.8 ± 1.4 9.4 ± 2.1 
    Hypoxia 17.0 ± 5.0 9.5 ± 2.0 13.3 ± 5.0 12.5 ± 2.0 
Heart rate (bpm)     
    Normoxia 65.6 ± 3.9 63.9 ± 2.4 66.4 ± 3.1 64.3 ± 2.5 
    Hypoxia 83.1 ± 5.0* 75.2 ± 3.3* 79.5 ± 3.4* 77.2 ± 3.4 
Arterial pressure (mmHg)     
    Normoxia 93.7 ± 4.0 94.7 ± 2.0 90.7 ± 3.8 92.3 ± 2.1 
    Hypoxia 104.1 ± 7.4 96.2 ± 2.6 93.9 ± 4.7 92.5 ± 2.6 
Variable/conditionSaline
Phentolamine
ControlDiabetesControlDiabetes
Hb saturation (%)     
    Normoxia 97.1 ± 0.3 97.4 ± 0.3 97.6 ± 0.2 97.0 ± 0.3 
    Hypoxia 82.1 ± 1.3* 81.9 ± 1.2* 83.4 ± 1.3* 83.6 ± 1.5* 
PO2 (mmHg)     
    Normoxia 91.9 ± 4.5 91.8 ± 3.3 92.3 ± 3.5 90.9 ± 3.6 
    Hypoxia 43.7 ± 1.1* 43.9 ± 0.9* 43.7 ± 0.5* 44.9 ± 1.4* 
PETCO2(mmHg)     
    Normoxia 36.3 ± 0.9 35.4 ± 2.9 35.8 ± 1.4 37.0 ± 1.8 
    Hypoxia 36.2 ± 1.1 34.0 ± 2.9 35.1 ± 1.1 35.7 ± 1.7 
pH     
    Normoxia 7.42 ± 0.01 7.40 ± 0.01 7.42 ± 0.01 7.41 ± 0.01 
    Hypoxia 7.43 ± 0.01 7.44 ± 0.01* 7.44 ± 0.01* 7.45 ± 0.01 
Minute ventilation (l/min BTPS)     
    Normoxia 6.4 ± 1.2 6.4 ± 1.1 6.8 ± 1.4 9.4 ± 2.1 
    Hypoxia 17.0 ± 5.0 9.5 ± 2.0 13.3 ± 5.0 12.5 ± 2.0 
Heart rate (bpm)     
    Normoxia 65.6 ± 3.9 63.9 ± 2.4 66.4 ± 3.1 64.3 ± 2.5 
    Hypoxia 83.1 ± 5.0* 75.2 ± 3.3* 79.5 ± 3.4* 77.2 ± 3.4 
Arterial pressure (mmHg)     
    Normoxia 93.7 ± 4.0 94.7 ± 2.0 90.7 ± 3.8 92.3 ± 2.1 
    Hypoxia 104.1 ± 7.4 96.2 ± 2.6 93.9 ± 4.7 92.5 ± 2.6 

Data are means ± SE.

*

P significant by Bonferroni-corrected post hoc t test, hypoxia versus normoxia;

P < 0.05, by two-way ANOVA, control versus diabetic subjects between normoxia and hypoxia within drug trial.

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