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TABLE 1

The effect of DC-41-33 on hormonal responses in the presence of SST, in batch-incubated islets

SST (nmol/l)DC-41-33 (μmol/l)Insulin (pmol · islet−1 · h−1)Glucagon (pg · islet−1 · h−1)
0.17 ± 0.01 30.8 ± 6.2 
0.22 ± 0.02* 158.7 ± 11.9* 
10 0.15 ± 0.01 11.0 ± 1.1 
10 0.24 ± 0.02* 138.7 ± 11.7* 
100 0.14 ± 0.01 13.4 ± 2.5 
100 0.20 ± 0.02* 68.1 ± 9.4* 
1,000 0.12 ± 0.01 13.3 ± 1.9 
1,000 0.17 ± 0.03* 25.2 ± 5.1 
SST (nmol/l)DC-41-33 (μmol/l)Insulin (pmol · islet−1 · h−1)Glucagon (pg · islet−1 · h−1)
0.17 ± 0.01 30.8 ± 6.2 
0.22 ± 0.02* 158.7 ± 11.9* 
10 0.15 ± 0.01 11.0 ± 1.1 
10 0.24 ± 0.02* 138.7 ± 11.7* 
100 0.14 ± 0.01 13.4 ± 2.5 
100 0.20 ± 0.02* 68.1 ± 9.4* 
1,000 0.12 ± 0.01 13.3 ± 1.9 
1,000 0.17 ± 0.03* 25.2 ± 5.1 

Data were obtained from the batch incubations shown in Fig. 2 and are presented as means ± SE of three experiments (three to five observations per experiment).

*

P < 0.001 vs. without DC-41-33;

P < 0.001 vs. 0 nmol/l SST + DC-41-33.

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