American Diabetes Association

TABLE 1

The effect of DC-41-33 on hormonal responses in the presence of SST, in batch-incubated islets

SST (nmol/l)	DC-41-33 (μmol/l)	Insulin (pmol · islet⁻¹ · h⁻¹)	Glucagon (pg · islet⁻¹ · h⁻¹)
0	0	0.17 ± 0.01	30.8 ± 6.2
0	2	0.22 ± 0.02^*	158.7 ± 11.9^*
10	0	0.15 ± 0.01	11.0 ± 1.1
10	2	0.24 ± 0.02^*	138.7 ± 11.7^*
100	0	0.14 ± 0.01	13.4 ± 2.5
100	2	0.20 ± 0.02^*	68.1 ± 9.4^*^†
1,000	0	0.12 ± 0.01	13.3 ± 1.9
1,000	2	0.17 ± 0.03^*	25.2 ± 5.1^†

SST (nmol/l)	DC-41-33 (μmol/l)	Insulin (pmol · islet⁻¹ · h⁻¹)	Glucagon (pg · islet⁻¹ · h⁻¹)
0	0	0.17 ± 0.01	30.8 ± 6.2
0	2	0.22 ± 0.02^*	158.7 ± 11.9^*
10	0	0.15 ± 0.01	11.0 ± 1.1
10	2	0.24 ± 0.02^*	138.7 ± 11.7^*
100	0	0.14 ± 0.01	13.4 ± 2.5
100	2	0.20 ± 0.02^*	68.1 ± 9.4^*^†
1,000	0	0.12 ± 0.01	13.3 ± 1.9
1,000	2	0.17 ± 0.03^*	25.2 ± 5.1^†

Data were obtained from the batch incubations shown in Fig. 2 and are presented as means ± SE of three experiments (three to five observations per experiment).

P < 0.001 vs. without DC-41-33;

†

P < 0.001 vs. 0 nmol/l SST + DC-41-33.

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