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TABLE 2

The effect of DC-41-33 on hormonal release in perfused pancreas

MinDC-41-33 (μmol/l)3.3 mmol/l glucose
5.5 mmol/l glucose
20% of the standard Ca2+ 3.3 mmol/l glucose
InsulinGlucagonInsulinGlucagonInsulinGlucagon
0–4 14.4 ± 2.9 9.6 ± 2.2 30.6 ± 5.0 4.7 ± 1.2 8.1 ± 1.5 8.2 ± 1.6 
0–4 9.8 ± 1.3 16.9 ± 2.2 24.7 ± 8.3 7.0 ± 1.2 3.7 ± 1.4 6.3 ± 1.4 
4–20 38.2 ± 6.2 33.3 ± 7.5 89.0 ± 14.6 19.1 ± 5.5 12.7 ± 2.3 28.1 ± 8.2 
4–20 38.2 ± 7.2 91.1 ± 20.2* 119.8 ± 36.3 47.0 ± 6.1 14.1 ± 3.6 32.8 ± 7.4 
0–20 52.6 ± 8.7 43.0 ± 9.6 119.7 ± 18.8 23.4 ± 6.4 20.8 ± 3.3 36.3 ± 9.5 
0–20 47.9 ± 8.4 108.0 ± 22.2* 144.5 ± 44.4 54.1 ± 7.2 17.7 ± 4.7 39.1 ± 8.8 
MinDC-41-33 (μmol/l)3.3 mmol/l glucose
5.5 mmol/l glucose
20% of the standard Ca2+ 3.3 mmol/l glucose
InsulinGlucagonInsulinGlucagonInsulinGlucagon
0–4 14.4 ± 2.9 9.6 ± 2.2 30.6 ± 5.0 4.7 ± 1.2 8.1 ± 1.5 8.2 ± 1.6 
0–4 9.8 ± 1.3 16.9 ± 2.2 24.7 ± 8.3 7.0 ± 1.2 3.7 ± 1.4 6.3 ± 1.4 
4–20 38.2 ± 6.2 33.3 ± 7.5 89.0 ± 14.6 19.1 ± 5.5 12.7 ± 2.3 28.1 ± 8.2 
4–20 38.2 ± 7.2 91.1 ± 20.2* 119.8 ± 36.3 47.0 ± 6.1 14.1 ± 3.6 32.8 ± 7.4 
0–20 52.6 ± 8.7 43.0 ± 9.6 119.7 ± 18.8 23.4 ± 6.4 20.8 ± 3.3 36.3 ± 9.5 
0–20 47.9 ± 8.4 108.0 ± 22.2* 144.5 ± 44.4 54.1 ± 7.2 17.7 ± 4.7 39.1 ± 8.8 

Data were obtained from the perfusion experiments shown in Figs. 4–6 and represent the amounts of insulin (pmol) and glucagon (ng) released during the 20-min stimulation period. Arginine (20 mmol/l) was used as the stimulus. The hormone amount is calculated as the area under the curve, using the secretion rate at min 0 as the basal value.

*

P < 0.02,

P < 0.005, and

P < 0.01 vs. without DC-41-33.

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