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TABLE 2

Urinary albumin excretion, podocyte, profibrotic growth factor, and proinflammatory cytokine mRNA expression in wild-type and Akita mice

Wild typeAkitaP value
Urinary albumin-to-creatinine ratio 0.3 ± 0.1 1.8 ± 0.1 <0.01 
Podocyte markers    
    Synaptopodin 30.2 ± 1.0 7.1 ± 0.8 <0.01 
    Podocin 44.9 ± 1.3 11.2 ± 0.7 <0.01 
Profibrotic growth factors    
    TGF-β 1.9 ± 0.1 4.1 ± 0.2 <0.05 
    PAI-1 0.9 ± 0.1 6.0 ± 0.2 <0.01 
Proinflammatory cytokines    
    VEGF 2.1 ± 0.2 3.6 ± 0.2 <0.05 
    TNF-α 1.7 ± 0.2 4.1 ± 0.3 <0.01 
Wild typeAkitaP value
Urinary albumin-to-creatinine ratio 0.3 ± 0.1 1.8 ± 0.1 <0.01 
Podocyte markers    
    Synaptopodin 30.2 ± 1.0 7.1 ± 0.8 <0.01 
    Podocin 44.9 ± 1.3 11.2 ± 0.7 <0.01 
Profibrotic growth factors    
    TGF-β 1.9 ± 0.1 4.1 ± 0.2 <0.05 
    PAI-1 0.9 ± 0.1 6.0 ± 0.2 <0.01 
Proinflammatory cytokines    
    VEGF 2.1 ± 0.2 3.6 ± 0.2 <0.05 
    TNF-α 1.7 ± 0.2 4.1 ± 0.3 <0.01 

Data are means ± SE (n = 6 mice in each group).

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