Urinary albumin excretion, podocyte, profibrotic growth factor, and proinflammatory cytokine mRNA expression in wild-type and Akita mice
| . | Wild type . | Akita . | P value . |
|---|---|---|---|
| Urinary albumin-to-creatinine ratio | 0.3 ± 0.1 | 1.8 ± 0.1 | <0.01 |
| Podocyte markers | |||
| Synaptopodin | 30.2 ± 1.0 | 7.1 ± 0.8 | <0.01 |
| Podocin | 44.9 ± 1.3 | 11.2 ± 0.7 | <0.01 |
| Profibrotic growth factors | |||
| TGF-β | 1.9 ± 0.1 | 4.1 ± 0.2 | <0.05 |
| PAI-1 | 0.9 ± 0.1 | 6.0 ± 0.2 | <0.01 |
| Proinflammatory cytokines | |||
| VEGF | 2.1 ± 0.2 | 3.6 ± 0.2 | <0.05 |
| TNF-α | 1.7 ± 0.2 | 4.1 ± 0.3 | <0.01 |
| . | Wild type . | Akita . | P value . |
|---|---|---|---|
| Urinary albumin-to-creatinine ratio | 0.3 ± 0.1 | 1.8 ± 0.1 | <0.01 |
| Podocyte markers | |||
| Synaptopodin | 30.2 ± 1.0 | 7.1 ± 0.8 | <0.01 |
| Podocin | 44.9 ± 1.3 | 11.2 ± 0.7 | <0.01 |
| Profibrotic growth factors | |||
| TGF-β | 1.9 ± 0.1 | 4.1 ± 0.2 | <0.05 |
| PAI-1 | 0.9 ± 0.1 | 6.0 ± 0.2 | <0.01 |
| Proinflammatory cytokines | |||
| VEGF | 2.1 ± 0.2 | 3.6 ± 0.2 | <0.05 |
| TNF-α | 1.7 ± 0.2 | 4.1 ± 0.3 | <0.01 |
Data are means ± SE (n = 6 mice in each group).