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TABLE 3

Nuclear receptor and lipid metabolism enzyme activity, protein, and mRNA expression in wild-type and Akita mice

Wild typeAkitaP value
Fatty acid synthesis    
    SREBP-1 protein 3.0 ± 0.2 5.4 ± 0.2 <0.01 
    SCD-1 mRNA 1.8 ± 0.2 3.6 ± 0.3 <0.05 
    SCD-1 protein 7.2 ± 0.1 11.6 ± 0.3 <0.05 
    SCD-1 activity 2.5 ± 0.1 4.2 ± 0.3 <0.05 
    FXR mRNA 9.1 ± 0.2 2.0 ± 0.4 <0.01 
    SHP mRNA 3.9 ± 0.2 2.1 ± 0.4 <0.05 
Cholesterol synthesis and efflux    
    SREBP-2 protein 1.6 ± 0.2 3.4 ± 0.3 <0.01 
    ABCA1 mRNA 14.8 ± 1.0 5.8 ± 0.9 <0.01 
    LXR-α 12.3 ± 0.8 3.1 ± 0.7 <0.01 
    LXR-β 12.9 ± 0.9 2.1 ± 0.8 <0.01 
Wild typeAkitaP value
Fatty acid synthesis    
    SREBP-1 protein 3.0 ± 0.2 5.4 ± 0.2 <0.01 
    SCD-1 mRNA 1.8 ± 0.2 3.6 ± 0.3 <0.05 
    SCD-1 protein 7.2 ± 0.1 11.6 ± 0.3 <0.05 
    SCD-1 activity 2.5 ± 0.1 4.2 ± 0.3 <0.05 
    FXR mRNA 9.1 ± 0.2 2.0 ± 0.4 <0.01 
    SHP mRNA 3.9 ± 0.2 2.1 ± 0.4 <0.05 
Cholesterol synthesis and efflux    
    SREBP-2 protein 1.6 ± 0.2 3.4 ± 0.3 <0.01 
    ABCA1 mRNA 14.8 ± 1.0 5.8 ± 0.9 <0.01 
    LXR-α 12.3 ± 0.8 3.1 ± 0.7 <0.01 
    LXR-β 12.9 ± 0.9 2.1 ± 0.8 <0.01 

Data are means ± SE (n = 6 mice in each group).

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