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TABLE 4

Podocyte, extracellular matrix protein, proinflammatory cytokine, and NADPH oxidase mRNA expression in wild-type and OVE26 mice

Wild typeOVE26P value
Podocyte markers    
    Podocin 86.2 ± 4.3 17.8 ± 6.8 <0.01 
    Synaptopodin 19.9 ± 3.1 5.6 ± 2.7 <0.01 
Extracellular matrix proteins    
    Fibronectin 39.2 ± 4.7 204.7 ± 6.1 <0.01 
    Type IV collagen 2.7 ± 0.3 12.6 ± 0.6 <0.01 
Proinflammatory cytokines    
    TNF-α 0.2 ± 0.3 1.8 ± 0.1 <0.01 
    IL-6 0.8 ± 0.4 7.2 ± 1.0 <0.01 
Oxidative stress    
    Nox4 12.8 ± 1.9 36.7 ± 2.1 <0.05 
    Phoxp22 2.4 ± 0.4 5.9 ± 0.5 <0.05 
    Phoxp47 5.8 ± 2.8 44.8 ± 3.9 <0.01 
    RAGE 16.8 ± 1.8 49.7 ± 3.7 <0.05 
Wild typeOVE26P value
Podocyte markers    
    Podocin 86.2 ± 4.3 17.8 ± 6.8 <0.01 
    Synaptopodin 19.9 ± 3.1 5.6 ± 2.7 <0.01 
Extracellular matrix proteins    
    Fibronectin 39.2 ± 4.7 204.7 ± 6.1 <0.01 
    Type IV collagen 2.7 ± 0.3 12.6 ± 0.6 <0.01 
Proinflammatory cytokines    
    TNF-α 0.2 ± 0.3 1.8 ± 0.1 <0.01 
    IL-6 0.8 ± 0.4 7.2 ± 1.0 <0.01 
Oxidative stress    
    Nox4 12.8 ± 1.9 36.7 ± 2.1 <0.05 
    Phoxp22 2.4 ± 0.4 5.9 ± 0.5 <0.05 
    Phoxp47 5.8 ± 2.8 44.8 ± 3.9 <0.01 
    RAGE 16.8 ± 1.8 49.7 ± 3.7 <0.05 

Data are means ± SE (n = 5 mice in each group).

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