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TABLE 5

Nuclear receptor and lipid metabolism enzyme mRNA expression in wild-type and OVE26 mice

Wild typeOVE26P value
Fatty acid synthesis    
    SREBP-1c 3.6 ± 0.5 7.1 ± 0.8 <0.05 
    ACC 3.2 ± 0.8 7.8 ± 0.7 <0.05 
    FAS 2.1 ± 0.5 4.8 ± 0.4 <0.05 
    ChREBP 1.4 ± 0.3 4.2 ± 0.4 <0.01 
    L-PK 7.1 ± 1.0 14.9 ± 1.2 <0.05 
Fatty acid oxidation    
    PPAR-α 12.1 ± 0.6 3.9 ± 0.9 <0.01 
    PPAR-δ 14.7 ± 0.5 4.0 ± 0.7 <0.01 
    ACO 4.6 ± 0.2 1.8 ± 0.3 <0.01 
    FXR 5.3 ± 0.3 2.3 ± 0.4 <0.05 
Cholesterol synthesis    
    SREBP-2 3.9 ± 0.6 12.7 ± 0.9 <0.01 
    HMG-CoA reductase 2.1 ± 0.3 5.1 ± 0.4 <0.05 
Cholesterol efflux    
    LXR-α 6.3 ± 0.4 3.1 ± 0.5 <0.05 
    LXR-β 22.1 ± 0.6 7.9 ± 0.9 <0.05 
    ABCA1 8.9 ± 0.4 3.7 ± 0.4 <0.05 
Wild typeOVE26P value
Fatty acid synthesis    
    SREBP-1c 3.6 ± 0.5 7.1 ± 0.8 <0.05 
    ACC 3.2 ± 0.8 7.8 ± 0.7 <0.05 
    FAS 2.1 ± 0.5 4.8 ± 0.4 <0.05 
    ChREBP 1.4 ± 0.3 4.2 ± 0.4 <0.01 
    L-PK 7.1 ± 1.0 14.9 ± 1.2 <0.05 
Fatty acid oxidation    
    PPAR-α 12.1 ± 0.6 3.9 ± 0.9 <0.01 
    PPAR-δ 14.7 ± 0.5 4.0 ± 0.7 <0.01 
    ACO 4.6 ± 0.2 1.8 ± 0.3 <0.01 
    FXR 5.3 ± 0.3 2.3 ± 0.4 <0.05 
Cholesterol synthesis    
    SREBP-2 3.9 ± 0.6 12.7 ± 0.9 <0.01 
    HMG-CoA reductase 2.1 ± 0.3 5.1 ± 0.4 <0.05 
Cholesterol efflux    
    LXR-α 6.3 ± 0.4 3.1 ± 0.5 <0.05 
    LXR-β 22.1 ± 0.6 7.9 ± 0.9 <0.05 
    ABCA1 8.9 ± 0.4 3.7 ± 0.4 <0.05 

Data are means ± SE (n = 5 mice in each group).

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