Nuclear receptor and lipid metabolism enzyme mRNA expression in wild-type and OVE26 mice
| . | Wild type . | OVE26 . | P value . |
|---|---|---|---|
| Fatty acid synthesis | |||
| SREBP-1c | 3.6 ± 0.5 | 7.1 ± 0.8 | <0.05 |
| ACC | 3.2 ± 0.8 | 7.8 ± 0.7 | <0.05 |
| FAS | 2.1 ± 0.5 | 4.8 ± 0.4 | <0.05 |
| ChREBP | 1.4 ± 0.3 | 4.2 ± 0.4 | <0.01 |
| L-PK | 7.1 ± 1.0 | 14.9 ± 1.2 | <0.05 |
| Fatty acid oxidation | |||
| PPAR-α | 12.1 ± 0.6 | 3.9 ± 0.9 | <0.01 |
| PPAR-δ | 14.7 ± 0.5 | 4.0 ± 0.7 | <0.01 |
| ACO | 4.6 ± 0.2 | 1.8 ± 0.3 | <0.01 |
| FXR | 5.3 ± 0.3 | 2.3 ± 0.4 | <0.05 |
| Cholesterol synthesis | |||
| SREBP-2 | 3.9 ± 0.6 | 12.7 ± 0.9 | <0.01 |
| HMG-CoA reductase | 2.1 ± 0.3 | 5.1 ± 0.4 | <0.05 |
| Cholesterol efflux | |||
| LXR-α | 6.3 ± 0.4 | 3.1 ± 0.5 | <0.05 |
| LXR-β | 22.1 ± 0.6 | 7.9 ± 0.9 | <0.05 |
| ABCA1 | 8.9 ± 0.4 | 3.7 ± 0.4 | <0.05 |
| . | Wild type . | OVE26 . | P value . |
|---|---|---|---|
| Fatty acid synthesis | |||
| SREBP-1c | 3.6 ± 0.5 | 7.1 ± 0.8 | <0.05 |
| ACC | 3.2 ± 0.8 | 7.8 ± 0.7 | <0.05 |
| FAS | 2.1 ± 0.5 | 4.8 ± 0.4 | <0.05 |
| ChREBP | 1.4 ± 0.3 | 4.2 ± 0.4 | <0.01 |
| L-PK | 7.1 ± 1.0 | 14.9 ± 1.2 | <0.05 |
| Fatty acid oxidation | |||
| PPAR-α | 12.1 ± 0.6 | 3.9 ± 0.9 | <0.01 |
| PPAR-δ | 14.7 ± 0.5 | 4.0 ± 0.7 | <0.01 |
| ACO | 4.6 ± 0.2 | 1.8 ± 0.3 | <0.01 |
| FXR | 5.3 ± 0.3 | 2.3 ± 0.4 | <0.05 |
| Cholesterol synthesis | |||
| SREBP-2 | 3.9 ± 0.6 | 12.7 ± 0.9 | <0.01 |
| HMG-CoA reductase | 2.1 ± 0.3 | 5.1 ± 0.4 | <0.05 |
| Cholesterol efflux | |||
| LXR-α | 6.3 ± 0.4 | 3.1 ± 0.5 | <0.05 |
| LXR-β | 22.1 ± 0.6 | 7.9 ± 0.9 | <0.05 |
| ABCA1 | 8.9 ± 0.4 | 3.7 ± 0.4 | <0.05 |
Data are means ± SE (n = 5 mice in each group).