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Table 1—

Patient clinical characteristics

ControlEpalrestatP
n 305 289  
Sex   0.742* 
    Male 174 (57.0) 161 (55.7)  
    Female 131 (43.0) 128 (44.3)  
Age (years) 61.5 (± 9.1) 61.5 (± 9.8) 0.958 
BMI (kg/m223.0 (± 3.4) 23.1 (± 3.2) 0.706 
Type of diabetes   0.299* 
    Type 1 6 (2.0) 9 (3.1)  
    Type 2 295 (96.7) 279 (96.5)  
    Other 4 (1.3) 1 (0.3)  
Duration of diabetes (years) 12.4 (± 8.0) 13.3 (± 8.9) 0.221 
A1C (%) 7.0 (± 1.0) 7.1 (± 1.0) 0.214 
Diabetes therapy   0.977 
    Diet alone 40 (13.1) 44 (15.2)  
    Oral hypoglycemic agent 151 (49.5) 133 (46.0)  
    Insulin 114 (37.4) 112 (38.8)  
Duration of neuropathy (years) 3.1 (± 3.5) 3.5 (± 4.6) 0.387 
Median MNCV (m/s) 52.5 (± 4.9) 52.1 (± 5.1) 0.277 
Diabetic retinopathy   0.171 
    No 157 (51.5) 135 (46.7)  
    Simple 82 (26.9) 79 (27.3)  
    Preproliferative 26 (8.5) 27 (9.3)  
    Proliferative 40 (13.1) 48 (16.6)  
Proteinuria   0.826 
    No 224 (73.4) 209 (72.3)  
    Microalbuminuria 30 (9.8) 33 (11.4)  
    Clinical albuminuria 51 (16.7) 47 (16.3)  
ControlEpalrestatP
n 305 289  
Sex   0.742* 
    Male 174 (57.0) 161 (55.7)  
    Female 131 (43.0) 128 (44.3)  
Age (years) 61.5 (± 9.1) 61.5 (± 9.8) 0.958 
BMI (kg/m223.0 (± 3.4) 23.1 (± 3.2) 0.706 
Type of diabetes   0.299* 
    Type 1 6 (2.0) 9 (3.1)  
    Type 2 295 (96.7) 279 (96.5)  
    Other 4 (1.3) 1 (0.3)  
Duration of diabetes (years) 12.4 (± 8.0) 13.3 (± 8.9) 0.221 
A1C (%) 7.0 (± 1.0) 7.1 (± 1.0) 0.214 
Diabetes therapy   0.977 
    Diet alone 40 (13.1) 44 (15.2)  
    Oral hypoglycemic agent 151 (49.5) 133 (46.0)  
    Insulin 114 (37.4) 112 (38.8)  
Duration of neuropathy (years) 3.1 (± 3.5) 3.5 (± 4.6) 0.387 
Median MNCV (m/s) 52.5 (± 4.9) 52.1 (± 5.1) 0.277 
Diabetic retinopathy   0.171 
    No 157 (51.5) 135 (46.7)  
    Simple 82 (26.9) 79 (27.3)  
    Preproliferative 26 (8.5) 27 (9.3)  
    Proliferative 40 (13.1) 48 (16.6)  
Proteinuria   0.826 
    No 224 (73.4) 209 (72.3)  
    Microalbuminuria 30 (9.8) 33 (11.4)  
    Clinical albuminuria 51 (16.7) 47 (16.3)  

Data are means ± SD or n (%).

*

P values were calculated using χ2 test,

two-sample t test, and

Mann-Whitney U test. Duration of neuropathy refers to mean patient-reported duration of neuropathy symptoms.

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