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TABLE 1

Association analyses of OAS1 A/G splice-acceptor site SNP (rs10774671) in 1,552 families

PopulationParent-child trios (n)Parental MAFTDT (G allele)
TNT%TRRP*
U.K. 706 0.34 340 322 51.4 1.06 0.48 
U.S. 592 0.39 229 259 46.9 0.88 0.17 
Norway 323 0.30 139 124 52.8 1.12 0.35 
Romania 292 0.36 133 138 49.0 0.96 0.76 
All families 1,913 0.34 841 843 49.9 1.00 0.96 
Unaffected sibs 856 0.34 369 375 49.6 0.98 0.83 
PopulationParent-child trios (n)Parental MAFTDT (G allele)
TNT%TRRP*
U.K. 706 0.34 340 322 51.4 1.06 0.48 
U.S. 592 0.39 229 259 46.9 0.88 0.17 
Norway 323 0.30 139 124 52.8 1.12 0.35 
Romania 292 0.36 133 138 49.0 0.96 0.76 
All families 1,913 0.34 841 843 49.9 1.00 0.96 
Unaffected sibs 856 0.34 369 375 49.6 0.98 0.83 
*

P values by TDT. MAF, minor allele frequency; NT, not transmitted; T, transmitted.

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