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TABLE 2

OAS1 A/G splice-acceptor site SNP (rs10774671) allele and genotype frequencies and association test results in the type 1 diabetes family and the case-control collection

Family collectionTransmittedUntransmitted*RR (95% CI)P
Allele   TDT  
    G (TDT) 841 843 1.00 (0.91–1.10) 0.96 
Genotype   Conditional logistic regression  
    AA 829 (43.3) 2,484 (43.3) 1.00 (ref.) — 
    GA 848 (44.4) 2,554 (44.5) 1.00 (0.88–1.13) 0.95 
    GG 236 (12.3) 701 (12.2) 1.01 (0.82–1.24) 0.92 
    GG+GA 1,084 (56.7) 3,255 (56.7) 1.00 (0.88–1.13) 0.96 
Family collectionTransmittedUntransmitted*RR (95% CI)P
Allele   TDT  
    G (TDT) 841 843 1.00 (0.91–1.10) 0.96 
Genotype   Conditional logistic regression  
    AA 829 (43.3) 2,484 (43.3) 1.00 (ref.) — 
    GA 848 (44.4) 2,554 (44.5) 1.00 (0.88–1.13) 0.95 
    GG 236 (12.3) 701 (12.2) 1.01 (0.82–1.24) 0.92 
    GG+GA 1,084 (56.7) 3,255 (56.7) 1.00 (0.88–1.13) 0.96 
Case-control collectionCases (n = 4,287)Control subjects (n = 4,735)OR (95% CI)P
Allele   Logistic regression  
    A 5,522 (64.4) 6,093 (64.3) 1.00 (ref.) — 
    G 3,052 (35.6) 3,377 (35.7) 0.99 (0.93–1.06) 0.83 
Genotype     
    AA 1,779 (41.5) 1,945 (41.1) 1.00 (ref.) — 
    GA 1,964 (45.8) 2,203 (46.5) 0.96 (0.88–1.05) 0.40 
    GG 544 (12.7) 587 (12.4) 1.01 (0.88–1.16) 0.86 
    GG+GA 2,508 (58.5) 2,790 (58.9) 0.97 (0.89–1.06) 0.52 
Case-control collectionCases (n = 4,287)Control subjects (n = 4,735)OR (95% CI)P
Allele   Logistic regression  
    A 5,522 (64.4) 6,093 (64.3) 1.00 (ref.) — 
    G 3,052 (35.6) 3,377 (35.7) 0.99 (0.93–1.06) 0.83 
Genotype     
    AA 1,779 (41.5) 1,945 (41.1) 1.00 (ref.) — 
    GA 1,964 (45.8) 2,203 (46.5) 0.96 (0.88–1.05) 0.40 
    GG 544 (12.7) 587 (12.4) 1.01 (0.88–1.16) 0.86 
    GG+GA 2,508 (58.5) 2,790 (58.9) 0.97 (0.89–1.06) 0.52 

Data are n (%) unless otherwise indicated. Families comprise U.K., U.S., Norway, and Romania.

*

Untransmitted (pseudo-control) data for genotypes in the type 1 diabetic family collection are estimated, as in Cordell and Clayton (13). OR, odds ratio.

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