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Table 1—

Postprandial glucose parameters after a standardized meal challenge and during a euglycemic clamp: results from week 12 and week 24

Inhaled insulin
Subcutaneous insulin
Adjusted inhaled-to-subcutaneous insulin ratio
BaselineWeek 12Week 24Adjusted week 24/baseline ratio*BaselineWeek 12Week 24Adjusted week 24/baseline ratio*
Glucose parameters after standardized meal challenge          
    Preprandial glucose (mg/dl) 130.2 ± 11.0 127.2 ± 8.1 127.6 ± 8.0 — 130.2 ± 10.7 133.3 ± 9.2 128.9 ± 9.5 — — 
    Prandial Cmax (mg/dl) 138.4 ± 17.9 137.6 ± 18.3 135.6 ± 14.1 0.98 142.9 ± 17.6 150.7 ± 17.4 138.5 ± 11.0 0.99 0.99 (0.95–1.03) 
    AUC0–120 (mg · min−1 · dl−113,395 ± 2,183 12,951 ± 2,374 12,855 ± 2,726 0.95 13,188 ± 2,351 14,954 ± 2,961 12,977 ± 2,445 0.97 0.98 (0.88–1.08) 
Parameters from euglycemic clamp studies          
    AUC-GIR0–120 (mg/kg) 259.0 ± 124.7 264.0 ± 149.4 222.2 ± 141.3 0.76 274.8 ± 141.2 237.5 ± 82.0 279.2 ± 126.7 1.02 0.75 (0.51–1.11) 
    GIRmax (mg · kg−1 · min−13.2 ± 1.3 3.1 ± 1.4 2.8 ± 1.4 0.83 3.8 ± 1.6 3.5 ± 1.3 3.5 ± 1.3 1.00 0.82 (0.68–1.00) 
    Duration of insulin action (t50-latet50-early) (min) 379.9 ± 162 354.1 ± 169.0 363.3 ± 150.8 −3 331.7 ± 124.5 373.9 ± 129.9 336.6 ± 130.5 −32 29 (−49 to 108) 
A1C 6.79 ± 0.70 6.63 ± 0.79 6.73 ± 0.87 — 7.13 ± 0.56 7.19 ± 0.85 7.08 ± 0.95 — — 
Inhaled insulin
Subcutaneous insulin
Adjusted inhaled-to-subcutaneous insulin ratio
BaselineWeek 12Week 24Adjusted week 24/baseline ratio*BaselineWeek 12Week 24Adjusted week 24/baseline ratio*
Glucose parameters after standardized meal challenge          
    Preprandial glucose (mg/dl) 130.2 ± 11.0 127.2 ± 8.1 127.6 ± 8.0 — 130.2 ± 10.7 133.3 ± 9.2 128.9 ± 9.5 — — 
    Prandial Cmax (mg/dl) 138.4 ± 17.9 137.6 ± 18.3 135.6 ± 14.1 0.98 142.9 ± 17.6 150.7 ± 17.4 138.5 ± 11.0 0.99 0.99 (0.95–1.03) 
    AUC0–120 (mg · min−1 · dl−113,395 ± 2,183 12,951 ± 2,374 12,855 ± 2,726 0.95 13,188 ± 2,351 14,954 ± 2,961 12,977 ± 2,445 0.97 0.98 (0.88–1.08) 
Parameters from euglycemic clamp studies          
    AUC-GIR0–120 (mg/kg) 259.0 ± 124.7 264.0 ± 149.4 222.2 ± 141.3 0.76 274.8 ± 141.2 237.5 ± 82.0 279.2 ± 126.7 1.02 0.75 (0.51–1.11) 
    GIRmax (mg · kg−1 · min−13.2 ± 1.3 3.1 ± 1.4 2.8 ± 1.4 0.83 3.8 ± 1.6 3.5 ± 1.3 3.5 ± 1.3 1.00 0.82 (0.68–1.00) 
    Duration of insulin action (t50-latet50-early) (min) 379.9 ± 162 354.1 ± 169.0 363.3 ± 150.8 −3 331.7 ± 124.5 373.9 ± 129.9 336.6 ± 130.5 −32 29 (−49 to 108) 
A1C 6.79 ± 0.70 6.63 ± 0.79 6.73 ± 0.87 — 7.13 ± 0.56 7.19 ± 0.85 7.08 ± 0.95 — — 

Data are means ± SD or ratio (90% CI).

*

Ratio of log-transformed data from a model including terms of treatment, week, and baseline measurement.

Week 24 change from baseline duration of insulin action.

Treatment group difference in change from baseline duration of insulin action.

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