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Table 2—

Cox proportional hazards analysis for predictors of ESRD in diabetic subjects seen in an urban academic nephrology clinic

CharacteristicP
Univariate analysis   
    HCV positive 3.69 (1.83–7.45) 0.0003 
Other significant factors   
    Sex (men) 1.84 (1.08–3.13) 0.026 
    African-American race 3.22 (1.00–10.3) 0.049 
    Diabetic nephropathy 2.23 (1.19–4.17) 0.012 
    Initial mean arterial blood pressure 1.02 (0.998–1.03) 0.081 
    Estimated GFR 0.947 (0.926–0.968) <0.0001 
    Urine protein (high) 3.72 (1.96–7.07) <0.0001 
    Number of blood pressure medications on presentation 1.27 (1.08–1.51) 0.0053 
    Systolic blood pressure on follow-up 1.03 (1.02–1.05) <0.0001 
    Diastolic blood pressure on follow-up 1.06 (1.03–1.10) 0.0002 
    Baseline total cholesterol (n = 115; 15 events) 0.979 (0.966–0.992) 0.0012 
Multivariate model   
HCV positive* 3.38 (1.39–8.21) 0.007 
HCV positive 3.49 (1.27–9.57) 0.015 
CharacteristicP
Univariate analysis   
    HCV positive 3.69 (1.83–7.45) 0.0003 
Other significant factors   
    Sex (men) 1.84 (1.08–3.13) 0.026 
    African-American race 3.22 (1.00–10.3) 0.049 
    Diabetic nephropathy 2.23 (1.19–4.17) 0.012 
    Initial mean arterial blood pressure 1.02 (0.998–1.03) 0.081 
    Estimated GFR 0.947 (0.926–0.968) <0.0001 
    Urine protein (high) 3.72 (1.96–7.07) <0.0001 
    Number of blood pressure medications on presentation 1.27 (1.08–1.51) 0.0053 
    Systolic blood pressure on follow-up 1.03 (1.02–1.05) <0.0001 
    Diastolic blood pressure on follow-up 1.06 (1.03–1.10) 0.0002 
    Baseline total cholesterol (n = 115; 15 events) 0.979 (0.966–0.992) 0.0012 
Multivariate model   
HCV positive* 3.38 (1.39–8.21) 0.007 
HCV positive 3.49 (1.27–9.57) 0.015 

Data are odds ratio (95% CI).

*

Model includes initial renal function, urine protein excretion, blood pressure, sex, race, and presence of diabetic nephropathy. In addition to HCV status, these factors remain significant on multivariate analysis (diastolic blood pressure on follow-up was the only blood pressure variable remaining significant).

Includes variable as above plus age, duration of diabetes, and renin angiotensin system inhibitor status at presentation. Age, initial renal function, and urine protein excretion remained significant in addition to HCV status.

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