Cox proportional hazards analysis for predictors of ESRD in diabetic subjects seen in an urban academic nephrology clinic
| Characteristic . | . | P . |
|---|---|---|
| Univariate analysis | ||
| HCV positive | 3.69 (1.83–7.45) | 0.0003 |
| Other significant factors | ||
| Sex (men) | 1.84 (1.08–3.13) | 0.026 |
| African-American race | 3.22 (1.00–10.3) | 0.049 |
| Diabetic nephropathy | 2.23 (1.19–4.17) | 0.012 |
| Initial mean arterial blood pressure | 1.02 (0.998–1.03) | 0.081 |
| Estimated GFR | 0.947 (0.926–0.968) | <0.0001 |
| Urine protein (high) | 3.72 (1.96–7.07) | <0.0001 |
| Number of blood pressure medications on presentation | 1.27 (1.08–1.51) | 0.0053 |
| Systolic blood pressure on follow-up | 1.03 (1.02–1.05) | <0.0001 |
| Diastolic blood pressure on follow-up | 1.06 (1.03–1.10) | 0.0002 |
| Baseline total cholesterol (n = 115; 15 events) | 0.979 (0.966–0.992) | 0.0012 |
| Multivariate model | ||
| HCV positive* | 3.38 (1.39–8.21) | 0.007 |
| HCV positive† | 3.49 (1.27–9.57) | 0.015 |
| Characteristic . | . | P . |
|---|---|---|
| Univariate analysis | ||
| HCV positive | 3.69 (1.83–7.45) | 0.0003 |
| Other significant factors | ||
| Sex (men) | 1.84 (1.08–3.13) | 0.026 |
| African-American race | 3.22 (1.00–10.3) | 0.049 |
| Diabetic nephropathy | 2.23 (1.19–4.17) | 0.012 |
| Initial mean arterial blood pressure | 1.02 (0.998–1.03) | 0.081 |
| Estimated GFR | 0.947 (0.926–0.968) | <0.0001 |
| Urine protein (high) | 3.72 (1.96–7.07) | <0.0001 |
| Number of blood pressure medications on presentation | 1.27 (1.08–1.51) | 0.0053 |
| Systolic blood pressure on follow-up | 1.03 (1.02–1.05) | <0.0001 |
| Diastolic blood pressure on follow-up | 1.06 (1.03–1.10) | 0.0002 |
| Baseline total cholesterol (n = 115; 15 events) | 0.979 (0.966–0.992) | 0.0012 |
| Multivariate model | ||
| HCV positive* | 3.38 (1.39–8.21) | 0.007 |
| HCV positive† | 3.49 (1.27–9.57) | 0.015 |
Data are odds ratio (95% CI).
Model includes initial renal function, urine protein excretion, blood pressure, sex, race, and presence of diabetic nephropathy. In addition to HCV status, these factors remain significant on multivariate analysis (diastolic blood pressure on follow-up was the only blood pressure variable remaining significant).
Includes variable as above plus age, duration of diabetes, and renin angiotensin system inhibitor status at presentation. Age, initial renal function, and urine protein excretion remained significant in addition to HCV status.