American Diabetes Association

Table 1—

Pharmacokinetic results for all patients

	Geometric mean											Point estimate (95% confidence limits)^*
		All			Children			Adolescents			All	Adolescents/children
		Glu	RHI	Glu	RHI	Glu	RHI	Glu/RHI	Glu	RHI
n	20	19	10	10	10	9	19	10	9
INS AUC_(0–1h) (μIU · min⁻¹ · ml⁻¹)	2,287	1,246	2,170	1,023	2,410	1,552	176% (127, 244)	111% (70, 175)	152% (89, 258)
INS AUC_(0–2h) (μIU · min⁻¹ · ml⁻¹)	5,232	2,994	4,948	2,383	5,534	3,860	169% (127, 224)	112% (72, 174)	162% (105, 250)
INS AUC_(0–4h) (μIU · min⁻¹ · ml⁻¹)	7,624	5,703	7,193	4,530	8,081	7,367	130% (99, 170)	112% (72, 175)	163% (111, 238)
INS AUC_(0–6h) (μIU · min⁻¹ · ml⁻¹)	8,361	7,052	7,934	5,581	8,811	9,145	116% (90, 150)	111% (73, 169)	164% (114, 236)
C_max (μIU/ml)	58	33	55	25	61	44	171% (127, 229)	112% (73, 172)	177% (112, 281)
t_max (min)	54^†	66^†	55^†	59^†	52	76^†	−8 min (−24, 7)^‡	−2 min (−9, 11)	9 min (−24, 49)
MRT (min)	88	137	87	132	90	144	64% (59, 70)	103% (88, 121)	110% (92, 130)

	Geometric mean											Point estimate (95% confidence limits)^*
		All			Children			Adolescents			All	Adolescents/children
		Glu	RHI	Glu	RHI	Glu	RHI	Glu/RHI	Glu	RHI
n	20	19	10	10	10	9	19	10	9
INS AUC_(0–1h) (μIU · min⁻¹ · ml⁻¹)	2,287	1,246	2,170	1,023	2,410	1,552	176% (127, 244)	111% (70, 175)	152% (89, 258)
INS AUC_(0–2h) (μIU · min⁻¹ · ml⁻¹)	5,232	2,994	4,948	2,383	5,534	3,860	169% (127, 224)	112% (72, 174)	162% (105, 250)
INS AUC_(0–4h) (μIU · min⁻¹ · ml⁻¹)	7,624	5,703	7,193	4,530	8,081	7,367	130% (99, 170)	112% (72, 175)	163% (111, 238)
INS AUC_(0–6h) (μIU · min⁻¹ · ml⁻¹)	8,361	7,052	7,934	5,581	8,811	9,145	116% (90, 150)	111% (73, 169)	164% (114, 236)
C_max (μIU/ml)	58	33	55	25	61	44	171% (127, 229)	112% (73, 172)	177% (112, 281)
t_max (min)	54^†	66^†	55^†	59^†	52	76^†	−8 min (−24, 7)^‡	−2 min (−9, 11)	9 min (−24, 49)
MRT (min)	88	137	87	132	90	144	64% (59, 70)	103% (88, 121)	110% (92, 130)

Point estimates (95% confidence limits) for the ratio of treatment means.

†

Median;

‡

point estimates (95% confidence limits) for the respective median differences from nonparametric data analysis. Glu, glulisine.