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Table 3—

Summary statistics for longitudinal change of nerve tests in group 2 patients

Nerve testRDNS patients (of 90) who at baseline had Σ 5 NC nds <97.5th percentile
Significantly worsened vs. improved over time
Worse*Better*Unchanged*P2
Ulnar CMAP nd 74 0.001 0.8815 0.000 
Ulnar MNCV nd 22 68 −0.043 <0.0001 0.086 
Ulnar MNDL nd 18 70 0.059 <0.0001 0.110 
Ulnar F-wave nd 18 68 0.028 <0.0001 0.048 
Peroneal CMAP nd 21 68 −0.033 <0.0001 0.053 
Peroneal MNCV nd 23 61 −0.054 <0.0001 0.120 
Peroneal MNDL nd 30 59 0.082 <0.0001 0.228 
Tibial CMAP nd 16 12 62 −0.004 0.6130 0.000 
Tibial MNCV nd 12 77 −0.026 0.0003 0.042 
Tibial MNDL nd 25 64 0.085 <0.0001 0.226 
Tibial F-wave nd 15 66 0.017 0.0410 0.023 
Sural SNAP nd 18 67 −0.044 <0.0001 0.102 
Σ 5 NC nds 42 47 0.296 <0.0001 0.354 
Σ Per. Tib. Ul. CMAP nds 16 67 0.035 0.0170 0.017 
Σ Per. Tib. CMAP & Sur. SNAP nds 28 61 0.082 <0.0001 0.082 
Σ Per. Tib. Ul. MNCV nds 25 65 0.122 <0.0001 0.145 
Σ Per. Tib. MNCV & Sur. SNCV nds 18 71 0.122 <0.0001 0.134 
Σ Per. Tib. MNCV, Sur. SNCV & Tib. F-wave nds 21 67 0.143 <0.0001 0.119 
Σ Per. Tib. Ul. MNCV & Per. Tib. F-wave nds 28 59 0.173 <0.0001 0.119 
Σ Per. Tib. Ul. MNDL nds 35 54 0.223 <0.0001 0.290 
NIS (total) 82 0.032 0.0418 0.011 
NIS (lower leg) 81 0.032 0.0383 0.010 
NSC severity (total) 86 −0.169 0.0523 0.042 
Left foot VDT step nd 11 74 −0.020 0.0927 0.007 
ln(Left foot CDT step) nd 11 77 0.024 0.0670 0.002 
Left foot HP: 5 step nd 81 −0.005 0.8535 0.006 
Left foot HP: 0.5 step nd 81 −0.013 0.6113 0.001 
Left foot HP: 5–0.5 step nd 79 −0.016 0.5154 0.000 
Nerve testRDNS patients (of 90) who at baseline had Σ 5 NC nds <97.5th percentile
Significantly worsened vs. improved over time
Worse*Better*Unchanged*P2
Ulnar CMAP nd 74 0.001 0.8815 0.000 
Ulnar MNCV nd 22 68 −0.043 <0.0001 0.086 
Ulnar MNDL nd 18 70 0.059 <0.0001 0.110 
Ulnar F-wave nd 18 68 0.028 <0.0001 0.048 
Peroneal CMAP nd 21 68 −0.033 <0.0001 0.053 
Peroneal MNCV nd 23 61 −0.054 <0.0001 0.120 
Peroneal MNDL nd 30 59 0.082 <0.0001 0.228 
Tibial CMAP nd 16 12 62 −0.004 0.6130 0.000 
Tibial MNCV nd 12 77 −0.026 0.0003 0.042 
Tibial MNDL nd 25 64 0.085 <0.0001 0.226 
Tibial F-wave nd 15 66 0.017 0.0410 0.023 
Sural SNAP nd 18 67 −0.044 <0.0001 0.102 
Σ 5 NC nds 42 47 0.296 <0.0001 0.354 
Σ Per. Tib. Ul. CMAP nds 16 67 0.035 0.0170 0.017 
Σ Per. Tib. CMAP & Sur. SNAP nds 28 61 0.082 <0.0001 0.082 
Σ Per. Tib. Ul. MNCV nds 25 65 0.122 <0.0001 0.145 
Σ Per. Tib. MNCV & Sur. SNCV nds 18 71 0.122 <0.0001 0.134 
Σ Per. Tib. MNCV, Sur. SNCV & Tib. F-wave nds 21 67 0.143 <0.0001 0.119 
Σ Per. Tib. Ul. MNCV & Per. Tib. F-wave nds 28 59 0.173 <0.0001 0.119 
Σ Per. Tib. Ul. MNDL nds 35 54 0.223 <0.0001 0.290 
NIS (total) 82 0.032 0.0418 0.011 
NIS (lower leg) 81 0.032 0.0383 0.010 
NSC severity (total) 86 −0.169 0.0523 0.042 
Left foot VDT step nd 11 74 −0.020 0.0927 0.007 
ln(Left foot CDT step) nd 11 77 0.024 0.0670 0.002 
Left foot HP: 5 step nd 81 −0.005 0.8535 0.006 
Left foot HP: 0.5 step nd 81 −0.013 0.6113 0.001 
Left foot HP: 5–0.5 step nd 79 −0.016 0.5154 0.000 

Data in bold are P values <0.05.

*

Statistically significant change (P < 0.05) of the nerve test over time of each patient using regression analysis. The mean ±SD number of neuropathic assessments was 7.8 ± 1.2.

Mean slope () of regression lines of nerve tests on time.

Mean of the correlation of nerve tests on time. CDT, cooling detection threshold; CMAP, compound muscle action potential; HP, heat pain; MNCV, motor nerve conduction velocity; MNDL, motor nerve distal latency; Per., peroneal; SNAP, sensory nerve action potential; Sur. sural; Tib., tibial; Ul., ulnar; VDT, vibratory detection threshold.

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