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Table 4—

Risk covariates for monotone worsening of nerve conductions in group 2 patients

Continuous univariate risk factors
nSpearman correlation coefficientP*
Characteristics
Age at last visit 90 0.2465 0.0192 
Average height 90 0.0047 0.9653 
Average weight 90 0.0453 0.6717 
Average body surface area 90 0.0358 0.7377 
Average BMI 90 0.0562 0.5989 
Average pulse 90 −0.1974 0.0621 
Average systolic blood pressure 90 0.4385 <0.0001 
Average diastolic blood pressure 90 0.0702 0.5110 
Average energy expenditure (per person) 90 −0.1507 0.1563 
Average 24-h proteinuria 90 0.4132 0.0001 
Average 24-h microalbuminuria 87 0.4662 <0.0001 
Duration of diabetes at last visit 90 −0.0587 0.5827 
Average fasting plasma glucose 90 0.0918 0.3894 
Average A1C 90 0.2919 0.0052 
Average creatinine 90 0.2854 0.0064 
Average cholesterol 90 0.1755 0.0980 
Average triglycerides 90 0.1876 0.0767 
Average HDL 90 −0.0764 0.4743 
Average apolipoprotein A-I 90 −0.0761 0.4760 
Average apolipoprotein A-II 90 0.0281 0.7924 
Average apolipoprotein E 90 0.2421 0.0215 
Average apolipoprotein B 90 0.1619 0.1274 
Average lipoprotein(a) 90 −0.0626 0.5576 
Smoking (pack-years) in last year 88 0.0936 0.3857 
Alcohol drinking in last year 88 0.2589 0.0149 
Smoking (pack-years) now 90 0.0316 0.7671 
Alcohol drinking now 90 0.2088 0.0483 
Average A1C½ × duration of diabetes at last visit⅛ 90 0.2190 0.0381 
Nephropathy stage 90 0.3568 0.0006 
Retinopathy stage 90 0.1036 0.3314 
Continuous univariate risk factors
nSpearman correlation coefficientP*
Characteristics
Age at last visit 90 0.2465 0.0192 
Average height 90 0.0047 0.9653 
Average weight 90 0.0453 0.6717 
Average body surface area 90 0.0358 0.7377 
Average BMI 90 0.0562 0.5989 
Average pulse 90 −0.1974 0.0621 
Average systolic blood pressure 90 0.4385 <0.0001 
Average diastolic blood pressure 90 0.0702 0.5110 
Average energy expenditure (per person) 90 −0.1507 0.1563 
Average 24-h proteinuria 90 0.4132 0.0001 
Average 24-h microalbuminuria 87 0.4662 <0.0001 
Duration of diabetes at last visit 90 −0.0587 0.5827 
Average fasting plasma glucose 90 0.0918 0.3894 
Average A1C 90 0.2919 0.0052 
Average creatinine 90 0.2854 0.0064 
Average cholesterol 90 0.1755 0.0980 
Average triglycerides 90 0.1876 0.0767 
Average HDL 90 −0.0764 0.4743 
Average apolipoprotein A-I 90 −0.0761 0.4760 
Average apolipoprotein A-II 90 0.0281 0.7924 
Average apolipoprotein E 90 0.2421 0.0215 
Average apolipoprotein B 90 0.1619 0.1274 
Average lipoprotein(a) 90 −0.0626 0.5576 
Smoking (pack-years) in last year 88 0.0936 0.3857 
Alcohol drinking in last year 88 0.2589 0.0149 
Smoking (pack-years) now 90 0.0316 0.7671 
Alcohol drinking now 90 0.2088 0.0483 
Average A1C½ × duration of diabetes at last visit⅛ 90 0.2190 0.0381 
Nephropathy stage 90 0.3568 0.0006 
Retinopathy stage 90 0.1036 0.3314 

Dichotomous univariate risk factors: characteristicsn
Median
Z statisticP
1st2nd1st2nd
Last available type of diabetes by C-peptide (type 1/type 2) 26 64 0.1790 0.3030 −2.4170 0.0157 
Sex (women/men) 40 50 0.2565 0.2870 −0.8364 0.4029 

Dichotomous univariate risk factors: characteristicsn
Median
Z statisticP
1st2nd1st2nd
Last available type of diabetes by C-peptide (type 1/type 2) 26 64 0.1790 0.3030 −2.4170 0.0157 
Sex (women/men) 40 50 0.2565 0.2870 −0.8364 0.4029 
Multivariate risk factors: independent variableParameter estimatesSEt statisticP
Intercept 0.4443 0.0429   
−1/(24-h microalbuminuria½0.5781 0.1318 4.39 0.001 
Multivariate risk factors: independent variableParameter estimatesSEt statisticP
Intercept 0.4443 0.0429   
−1/(24-h microalbuminuria½0.5781 0.1318 4.39 0.001 

Change for variable periods up to 18 years. Data in bold are P values <0.05.

*

Two-sided Spearman rank correlation test.

Wilcoxon rank-sum test.

Least-squares multiple regression

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