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Table 2—

HR of death from all causes and coronary heart disease according to diabetes and depression diagnoses in 1982

No diabetes, not depressedNo diabetes, depressedDiabetes, not depressedDiabetes, depressed
n 7,032 2,278 453 262 
Person-years of follow-up 59,934 18,616 3,371 1,703 
All-cause mortality     
    Deaths (n1,147 478 166 134 
    Mortality rate (per 1,000) 19.1 25.7 49.2 78.7 
    Hazard ratio (95% CI)     
Multivariate model 1 1.00 (reference) 1.34 (1.16–1.54) 1.96 (1.63–2.35)* 3.27 (2.66–4.01)* 
Multivariate model 2 1.00 (reference) 1.20 (1.03–1.40) 1.88 (1.55–2.27) 2.50 (2.04–3.08) 
CHD mortality     
    Deaths (n301 125 55 41 
    Mortality rate (per 1,000) 5.0 6.7 16.3 24.1 
    HR (95% CI)     
Multivariate model 1 1.00 (reference) 1.46 (1.09–1.95) 2.51 (1.81–3.47) 3.46 (2.41–4.96) 
Multivariate model 2 1.00 (reference) 1.29 (0.96–1.74) 2.26 (1.60–3.21)§ 2.43 (1.66–3.56)§ 
No diabetes, not depressedNo diabetes, depressedDiabetes, not depressedDiabetes, depressed
n 7,032 2,278 453 262 
Person-years of follow-up 59,934 18,616 3,371 1,703 
All-cause mortality     
    Deaths (n1,147 478 166 134 
    Mortality rate (per 1,000) 19.1 25.7 49.2 78.7 
    Hazard ratio (95% CI)     
Multivariate model 1 1.00 (reference) 1.34 (1.16–1.54) 1.96 (1.63–2.35)* 3.27 (2.66–4.01)* 
Multivariate model 2 1.00 (reference) 1.20 (1.03–1.40) 1.88 (1.55–2.27) 2.50 (2.04–3.08) 
CHD mortality     
    Deaths (n301 125 55 41 
    Mortality rate (per 1,000) 5.0 6.7 16.3 24.1 
    HR (95% CI)     
Multivariate model 1 1.00 (reference) 1.46 (1.09–1.95) 2.51 (1.81–3.47) 3.46 (2.41–4.96) 
Multivariate model 2 1.00 (reference) 1.29 (0.96–1.74) 2.26 (1.60–3.21)§ 2.43 (1.66–3.56)§ 

Mortality rate was calculated with person-years of follow-up as denominator. CHD was defined by ICD-9 codes 410–414. Multivariate model 1 was adjusted for age in 1982 (years), sex, race/ethnicity (white vs. black/other), poverty:income ratio (<125, 125–399, ≥400%), education (<high school, high school, >high school), marital status (not married vs. married). Multivariate model 2 included additional adjustments for smoking (never, former, current), physical activity (light, regular, sedentary), BMI (<18.5, 18.5–24.9, 25.0–29.9, ≥30 kg/m2), aspirin use (yes vs. no), and comorbid conditions at baseline (cancer, hypertension, heart disease, stroke).

*

Comparison of diabetes, depressed vs. diabetes, and not depressed for model 1 significantly different (OR 1.67 [95% CI 1.30–2.14]).

Comparison of diabetes, depressed vs. diabetes, and not depressed for model 2 significantly different (OR 1.33 [1.02–1.74]).

Comparison of diabetes, depressed vs. diabetes, and not depressed for model 1 significantly different (OR 1.38 [0.89–2.12]).

§

Comparison of diabetes, depressed vs. diabetes, and not depressed for model 2 significantly different (OR 1.07 [0.67–1.71]).

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