Skip to Main Content
Table 1—

Baseline characteristics across quartiles of sTNF-RII among 929 women with type 2 diabetes: the NHS

Quartiles of sTNF-RII
1234
Median sTNF-RII (pg/ml) 1768.6 2205.1 2616.7 3322.7 
Range sTNF-RII (pg/ml) 1,005.1–2,006.8 2,010.8–2,370.6 2,373.2–2,888.1 2,891.6–9,355.3 
Age (years) 56.6 57.7 59.0 60.0 
BMI (kg/m227.3 29.2 30.9 32.4 
Current smokers 32 (14) 25 (11) 39 (17) 35 (14) 
Physical activity (h/week) 3.0 2.8 2.8 2.3 
Alcohol consumption (g/day) 4.5 2.7 2.2 1.9 
Duration of type 2 diabetes (years) 7.4 7.9 7.1 9.1 
Daily aspirin use 74 (33) 72 (32) 81 (35) 87 (35) 
Postmenopausal hormone use 68 (30) 66 (29) 62 (27) 57 (23) 
Insulin use 32 (14) 36 (16) 39 (17) 72 (29) 
Oral diabetic medication use 38 (17) 52 (23) 42 (18) 54 (22) 
Multivitamin supplement use 95 (42) 86 (38) 79 (34) 94 (38) 
History of hypertension 115 (51) 120 (53) 143 (62) 170 (69) 
History of hypercholesterolemia 126 (56) 118 (52) 120 (52) 131 (53) 
History of angina pectoris 27 (12) 18 (8) 28 (12) 27 (11) 
Parental history of MI 43 (19) 56 (25) 55 (24) 59 (24) 
Biomarkers     
HbA1c (%) 6.45 6.87 6.80 7.29 
CRP (mg/l)* 4.7 7.2 8.8 11.7 
sICAM-1 (ng/ml) 271.1 290.6 325.5 374.6 
sE-selectin (ng/ml) 55.7 60.0 68.5 79.5 
Fibrinogen (mg/dl) 349.4 367.5 386.2 397.4 
Triglycerides (mg/dl)  187.2 203.0 200.3 217.7 
HDL cholesterol (mg/dl) 56.0 52.6 49.5 48.6 
LDL cholesterol (mg/dl) 145.5 137.7 138.7 135.2 
Apolipoprotein B100 (mg/dl) 103.4 101.9 101.7 102.1 
Total cholesterol–to–HDL cholesterol ratio 4.6 4.7 4.7 4.9 
Quartiles of sTNF-RII
1234
Median sTNF-RII (pg/ml) 1768.6 2205.1 2616.7 3322.7 
Range sTNF-RII (pg/ml) 1,005.1–2,006.8 2,010.8–2,370.6 2,373.2–2,888.1 2,891.6–9,355.3 
Age (years) 56.6 57.7 59.0 60.0 
BMI (kg/m227.3 29.2 30.9 32.4 
Current smokers 32 (14) 25 (11) 39 (17) 35 (14) 
Physical activity (h/week) 3.0 2.8 2.8 2.3 
Alcohol consumption (g/day) 4.5 2.7 2.2 1.9 
Duration of type 2 diabetes (years) 7.4 7.9 7.1 9.1 
Daily aspirin use 74 (33) 72 (32) 81 (35) 87 (35) 
Postmenopausal hormone use 68 (30) 66 (29) 62 (27) 57 (23) 
Insulin use 32 (14) 36 (16) 39 (17) 72 (29) 
Oral diabetic medication use 38 (17) 52 (23) 42 (18) 54 (22) 
Multivitamin supplement use 95 (42) 86 (38) 79 (34) 94 (38) 
History of hypertension 115 (51) 120 (53) 143 (62) 170 (69) 
History of hypercholesterolemia 126 (56) 118 (52) 120 (52) 131 (53) 
History of angina pectoris 27 (12) 18 (8) 28 (12) 27 (11) 
Parental history of MI 43 (19) 56 (25) 55 (24) 59 (24) 
Biomarkers     
HbA1c (%) 6.45 6.87 6.80 7.29 
CRP (mg/l)* 4.7 7.2 8.8 11.7 
sICAM-1 (ng/ml) 271.1 290.6 325.5 374.6 
sE-selectin (ng/ml) 55.7 60.0 68.5 79.5 
Fibrinogen (mg/dl) 349.4 367.5 386.2 397.4 
Triglycerides (mg/dl)  187.2 203.0 200.3 217.7 
HDL cholesterol (mg/dl) 56.0 52.6 49.5 48.6 
LDL cholesterol (mg/dl) 145.5 137.7 138.7 135.2 
Apolipoprotein B100 (mg/dl) 103.4 101.9 101.7 102.1 
Total cholesterol–to–HDL cholesterol ratio 4.6 4.7 4.7 4.9 

Data are n (%) unless otherwise indicated. Means and percentages (except for age) are age adjusted for the age-groups: <49, 50–54, 55–59, 60–64, and ≥65 years.

*

According to a regression between two CRP assays among subgroup of 204 diabetic women (r = 0.97 corrected CRP = 0.4 + 0.67x).

Similar levels among 622 women who reported fasting >8 h before blood was drawn.

Close Modal

or Create an Account

Close Modal
Close Modal