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Table 2—

Relative risks of MI, CABG/PTCA, and total CHD events across quartiles of sTNF-RII among 929 women with type 2 diabetes: the NHS

Quartiles of sTNF-RII
1234P value
Median (pg/ml) 1,768.6 2,205.1 2,616.7 3,322.7  
MI (fatal + nonfatal)      
    n 16 16 28  
    Age adjusted 1.00 1.89 (0.81–4.41) 1.80 (0.77–4.22) 3.01 (1.37–6.64) 0.005 
    MV* 1.00 1.86 (0.78–4.41) 1.62 (0.67–3.88) 2.48 (1.08–5.69) 0.034 
CABG/PTCA      
    n 13 14 23  
    Age adjusted 1.00 0.46 (0.18–1.22) 1.04 (0.48–2.22) 1.64 (0.82–3.27) 0.031 
    MV* 1.00 0.53 (0.20–1.41) 1.07 (0.49–2.37) 1.77 (0.84–3.70) 0.041 
CHD (MI + CABG/PTCA)      
    n 21 22 30 51  
    Age adjusted 1.00 1.02 (0.56–1.85) 1.33 (0.76–2.33) 2.16 (1.29–3.62) <0.001 
    MV* 1.00 1.09 (0.60–2.01) 1.28 (0.72–2.29) 2.02 (1.17–3.48) 0.003 
    MV + duration of type 2 diabetes  1.02 (0.55–1.87) 1.25 (0.67–2.22) 1.87 (1.08–3.23) 0.007 
    MV + TGs 1.00 1.11 (0.61–2.04) 1.26 (0.70–2.24) 1.99 (1.16–3.45) 0.005 
    MV + HbA1c 1.00 1.03 (0.56–1.89) 1.19 (0.67–2.13) 1.79 (1.04–3.10) 0.014 
    MV + CRP 1.00 1.08 (0.59–1.99) 1.27 (0.71–2.28) 2.04 (1.17–3.56) 0.004 
    MV + HbA1c + CRP 1.00 1.03 (0.56–1.90) 1.21 (0.68–2.16) 1.86 (1.06–3.25) 0.011 
Quartiles of sTNF-RII
1234P value
Median (pg/ml) 1,768.6 2,205.1 2,616.7 3,322.7  
MI (fatal + nonfatal)      
    n 16 16 28  
    Age adjusted 1.00 1.89 (0.81–4.41) 1.80 (0.77–4.22) 3.01 (1.37–6.64) 0.005 
    MV* 1.00 1.86 (0.78–4.41) 1.62 (0.67–3.88) 2.48 (1.08–5.69) 0.034 
CABG/PTCA      
    n 13 14 23  
    Age adjusted 1.00 0.46 (0.18–1.22) 1.04 (0.48–2.22) 1.64 (0.82–3.27) 0.031 
    MV* 1.00 0.53 (0.20–1.41) 1.07 (0.49–2.37) 1.77 (0.84–3.70) 0.041 
CHD (MI + CABG/PTCA)      
    n 21 22 30 51  
    Age adjusted 1.00 1.02 (0.56–1.85) 1.33 (0.76–2.33) 2.16 (1.29–3.62) <0.001 
    MV* 1.00 1.09 (0.60–2.01) 1.28 (0.72–2.29) 2.02 (1.17–3.48) 0.003 
    MV + duration of type 2 diabetes  1.02 (0.55–1.87) 1.25 (0.67–2.22) 1.87 (1.08–3.23) 0.007 
    MV + TGs 1.00 1.11 (0.61–2.04) 1.26 (0.70–2.24) 1.99 (1.16–3.45) 0.005 
    MV + HbA1c 1.00 1.03 (0.56–1.89) 1.19 (0.67–2.13) 1.79 (1.04–3.10) 0.014 
    MV + CRP 1.00 1.08 (0.59–1.99) 1.27 (0.71–2.28) 2.04 (1.17–3.56) 0.004 
    MV + HbA1c + CRP 1.00 1.03 (0.56–1.90) 1.21 (0.68–2.16) 1.86 (1.06–3.25) 0.011 

Data are RR (95% CI) unless noted.

*

Multivariate model (MV), Cox regression, adjusted for age (<49, 50–54, 55–59, 60–64, ≥65 years), smoking (current, past, never), BMI (<23, 23–25, 25–28, 28–30, 30–34, ≥35 kg/m2), alcohol intake (0, 0.1–4.9, ≥5 g/day), physical activity (0–1, 1–2, 2–4, ≥4 h/week), postmenopausal hormone use (premenopausal, current, past, never, missing), aspirin use (nondaily, daily), parental history of MI, history of hypertension, history of reported angina pectoris, and ratio of total cholesterol to HDL (quartiles).

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