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TABLE 2

Glucose-stimulated insulin release of control and adenovirus-treated islets with and without exposure to cytotoxic agents

TreatmentGlucose ConcentrationUnmodifiedAd-LacZ*Ad-MnSOD*
No Treatment 3 mmol/l 511 ± 95 622 ± 113 490 ± 82 
 20 mmol/l 3,490 ± 130 3,933 ± 93 3,450 ± 179 
 Fold increase 6.8 6.3 7.0 
Alloxan 3 mmol/l 1,462 ± 186 592 ± 254 587 ± 135 
 20 mmol/l 3,643 ± 260 1,498 ± 367 4,123 ± 119 
 Fold increase 2.5 2.5 7.0 
SNAP 3 mmol/l 1,245 ± 49 640 ± 42 1,195 ± 35 
 20 mmol/l 715 ± 162 495 ± 261 980 ± 113 
 Fold increase 0.6 0.8 0.8 
Cytokines 3 mmol/l 1,145 ± 132 390 ± 41 2,128 ± 220 
 20 mmol/l 1,381 ± 241 504 ± 26 4,266 ± 367 
 Fold increase 1.2 1.3 2.0 
TreatmentGlucose ConcentrationUnmodifiedAd-LacZ*Ad-MnSOD*
No Treatment 3 mmol/l 511 ± 95 622 ± 113 490 ± 82 
 20 mmol/l 3,490 ± 130 3,933 ± 93 3,450 ± 179 
 Fold increase 6.8 6.3 7.0 
Alloxan 3 mmol/l 1,462 ± 186 592 ± 254 587 ± 135 
 20 mmol/l 3,643 ± 260 1,498 ± 367 4,123 ± 119 
 Fold increase 2.5 2.5 7.0 
SNAP 3 mmol/l 1,245 ± 49 640 ± 42 1,195 ± 35 
 20 mmol/l 715 ± 162 495 ± 261 980 ± 113 
 Fold increase 0.6 0.8 0.8 
Cytokines 3 mmol/l 1,145 ± 132 390 ± 41 2,128 ± 220 
 20 mmol/l 1,381 ± 241 504 ± 26 4,266 ± 367 
 Fold increase 1.2 1.3 2.0 

Values shown are ng/ml insulin after 30 min of static incubation. Table shows means ± SD of duplicate samples from three to six experiments. Fold increase was calculated by dividing the mean value of the high glucose concentration (20 mmol/l) by the mean value of the low concentration (3 mmol/l).

*

Islets were infected with either Ad-LacZ or Ad-MnSOD at 100 multiplicity of infection.

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