American Diabetes Association

TABLE 3

Poisson regression analyses of the ability of candidate indexes of IR to predict incident diabetes, with combined analysis using data from the SAHS, the MCDS, and the IRAS

Index	Unadjusted									Adjusted for age, sex, systolic blood pressure, HDL cholesterol, and BMI
		AROC curve					Top 10% vs. bottom 90%			AROC curve	Top 10% vs. bottom 90%
		%	Rank	P^*	RR	Rank	%	Rank	RR	Rank
-ISI_{0, 120}	78.5	1	—	5.84	1	81.6	1	3.13	1
-ISIgly_a	74.0	2	<0.0001	3.40	3	79.6	2	1.79	9
-SiM	73.1	3	0.24	4.22	2	79.4	3	2.11	2
-ISIgly_b	71.5	4	0.081	3.29	6.5	78.0	6	1.85	4.5
-QUICKI	71.5	5	0.28	3.29	6.5	78.1	5	1.85	4.5
-Stum_nodem	71.0	6	0.79	3.17	10	77.8	7	1.71	11
-BFSI	69.6	7	0.27	3.05	11	77.3	9	1.75	10
-ISI-2h	68.0	8	0.25	3.38	4	78.7	4	1.82	8
-McAuley	67.8	9	0.91	2.56	13	77.1	10	1.53	12
In(FI)	67.8	10	0.99	2.55	16.5	77.0	11	1.53	13.5
-Stum_wdem	67.4	11	0.96	2.57	12	76.5	13	1.13	17
-ISI	67.2	12	0.72	3.29	6.5	77.5	8	1.85	4.5
BMI	66.4	13	0.61	2.56	14	75.3	19	0.70	19
-Raynaud	66.1	14	0.85	2.55	16.5	76.9	12	1.53	13.5
FIRI	63.6	15	0.0009	3.29	6.5	76.3	14	1.85	4.5
HOMA-IR	62.8	16	0.99	3.20	9	76.0	15	1.82	7
FI	59.7	17	<0.0001	2.55	15	75.9	16	1.53	15
IGR	55.7	18	<0.0001	1.81	18	75.5	18	1.17	16
IGR-2h	55.1	19	0.96	1.64	19	75.6	17	1.06	18

Index	Unadjusted									Adjusted for age, sex, systolic blood pressure, HDL cholesterol, and BMI
		AROC curve					Top 10% vs. bottom 90%			AROC curve	Top 10% vs. bottom 90%
		%	Rank	P^*	RR	Rank	%	Rank	RR	Rank
-ISI_{0, 120}	78.5	1	—	5.84	1	81.6	1	3.13	1
-ISIgly_a	74.0	2	<0.0001	3.40	3	79.6	2	1.79	9
-SiM	73.1	3	0.24	4.22	2	79.4	3	2.11	2
-ISIgly_b	71.5	4	0.081	3.29	6.5	78.0	6	1.85	4.5
-QUICKI	71.5	5	0.28	3.29	6.5	78.1	5	1.85	4.5
-Stum_nodem	71.0	6	0.79	3.17	10	77.8	7	1.71	11
-BFSI	69.6	7	0.27	3.05	11	77.3	9	1.75	10
-ISI-2h	68.0	8	0.25	3.38	4	78.7	4	1.82	8
-McAuley	67.8	9	0.91	2.56	13	77.1	10	1.53	12
In(FI)	67.8	10	0.99	2.55	16.5	77.0	11	1.53	13.5
-Stum_wdem	67.4	11	0.96	2.57	12	76.5	13	1.13	17
-ISI	67.2	12	0.72	3.29	6.5	77.5	8	1.85	4.5
BMI	66.4	13	0.61	2.56	14	75.3	19	0.70	19
-Raynaud	66.1	14	0.85	2.55	16.5	76.9	12	1.53	13.5
FIRI	63.6	15	0.0009	3.29	6.5	76.3	14	1.85	4.5
HOMA-IR	62.8	16	0.99	3.20	9	76.0	15	1.82	7
FI	59.7	17	<0.0001	2.55	15	75.9	16	1.53	15
IGR	55.7	18	<0.0001	1.81	18	75.5	18	1.17	16
IGR-2h	55.1	19	0.96	1.64	19	75.6	17	1.06	18

Ordering of indexes in this table were maintained based on ranking in the unadjusted AROC column. For consistency in the direction of the associations in the tables, we have taken the negative of indices that estimate S_I (versus insulin resistance).

P value from algorithm developed by DeLong et al. (27), showing significance of difference in AROC for each index from one directly above it (i.e., having the next highest AROC). BFSI, Bennett’s fasting insulin sensitivity index; FI, fasting insulin; IGR, insulin/glucose ratio; Stum_wdem, Stumvoll index with demographic variables.

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