TABLE 4

Estimated haplotype frequencies in the sample groups

Haplotype (type 1 diabetes defined)Haplotype*UKPDS LADAW2 Repository LADAExeter YT2D LADAAll casesControl subjects
n  232 131 37 400 332 
Class ID− ACT 0.440 0.386 0.297 0.409 0.336 
Class IC+/ID+ ACC and AAC 0.401 0.385 0.568 0.411 0.364 
Class III PH TAC 0.115 0.190 0.122 0.140 0.222 
Class III VPH TCC 0.045 0.039 0.014 0.040 0.078 
P  1.7 × 10−6 0.056 1.0 × 10−3 7.9 × 10−6  
Haplotype (type 1 diabetes defined)Haplotype*UKPDS LADAW2 Repository LADAExeter YT2D LADAAll casesControl subjects
n  232 131 37 400 332 
Class ID− ACT 0.440 0.386 0.297 0.409 0.336 
Class IC+/ID+ ACC and AAC 0.401 0.385 0.568 0.411 0.364 
Class III PH TAC 0.115 0.190 0.122 0.140 0.222 
Class III VPH TCC 0.045 0.039 0.014 0.040 0.078 
P  1.7 × 10−6 0.056 1.0 × 10−3 7.9 × 10−6  
*

Allelic combination at −23HphI, +1404Fnu4HI, and +3580MspI SNPs. P = haplotype trend regression P value to test for difference in haplotype frequency distributions between case and control subjects.

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