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Table 3—

Genotype and allele frequencies of the 5′-(CA)n and promoter C/T polymorphisms in Chinese type 2 diabetic patients classified according to the presence or absence of nephropathy or retinopathy in subgroups.

UncomplicatedDiabetic nephropathyDiabetic retinopathyBoth diabetic nephropathy and retinopathy
n 92 159 66 121 
Genotype frequency (%)     
 x/x, x/z+6, z+6/z+6 89.1/10.9/0 90.6/9.4/0 93.9/4.5/1.5 96.7/3.3/0 
 x/x, x/z−2, z−2/z−2 68.5/29.3/2.2 61.0/34.6/4.4 62.1/31.8/6.1 57.0/34.7/8.3 
 CC, CT, TT 69.6/23.9/6.5 64.2/32.7/3.1 66.7/28.8/4.5 55.4/36.4/8.3 
Allele frequency (%)     
 z+6 5.5 4.7 3.9 1.7 
 z−2 16.9 21.7 22.0 25.7* 
 C 81.5 80.5 81.1 73.6 
 T 18.5 19.5 18.9 26.4* 
UncomplicatedDiabetic nephropathyDiabetic retinopathyBoth diabetic nephropathy and retinopathy
n 92 159 66 121 
Genotype frequency (%)     
 x/x, x/z+6, z+6/z+6 89.1/10.9/0 90.6/9.4/0 93.9/4.5/1.5 96.7/3.3/0 
 x/x, x/z−2, z−2/z−2 68.5/29.3/2.2 61.0/34.6/4.4 62.1/31.8/6.1 57.0/34.7/8.3 
 CC, CT, TT 69.6/23.9/6.5 64.2/32.7/3.1 66.7/28.8/4.5 55.4/36.4/8.3 
Allele frequency (%)     
 z+6 5.5 4.7 3.9 1.7 
 z−2 16.9 21.7 22.0 25.7* 
 C 81.5 80.5 81.1 73.6 
 T 18.5 19.5 18.9 26.4* 
*

P < 0.05 compared with UC group. x = any other (CA)n allele. Uncomplicated: patients free of microvascular complications and with ≥5 years disease duration.

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