RH of type 2 diabetes over 6 years of follow-up by quartile of depressive symptoms for 11,615 individuals age 48–67 years
| . | Quartile of depressive symptoms . | . | . | . | P value for trend . | |||
|---|---|---|---|---|---|---|---|---|
| . | Quartile 1 . | Quartile 2 . | Quartile 3 . | Quartile 4 . | . | |||
| Model 1: adjusted for age, race, ARIC center, education, and sex | 1.0 | 1.22 (0.99–1.51) | 1.31 (0.89–1.43) | 1.63 (1.31–2.02)‖ | <0.0001 | |||
| Model 2: adjusted for metabolic covariates* | 1.0 | 1.13 (0.9–1.40) | 1.06 (0.84–1.35) | 1.38 (1.10–1.73)‖ | 0.0071 | |||
| Model 3: adjusted for lifestyle covariates† | 1.0 | 1.20 (0.97–1.48) | 1.09 (0.86–1.38) | 1.51 (1.21–1.89)‖ | 0.0005 | |||
| Model 4: adjusted for lifestyle covariates and BMI‡ | 1.0 | 1.16 (0.94–1.43) | 1.02 (0.81–1.30) | 1.28 (1.02–1.60)‖ | 0.06 | |||
| Model 5: adjusted for metabolic and lifestyle covariates§ | 1.0 | 1.12 (0.90–1.39) | 1.03 (0.81–1.31) | 1.31 (1.04–1.64)‖ | 0.04 | |||
| . | Quartile of depressive symptoms . | . | . | . | P value for trend . | |||
|---|---|---|---|---|---|---|---|---|
| . | Quartile 1 . | Quartile 2 . | Quartile 3 . | Quartile 4 . | . | |||
| Model 1: adjusted for age, race, ARIC center, education, and sex | 1.0 | 1.22 (0.99–1.51) | 1.31 (0.89–1.43) | 1.63 (1.31–2.02)‖ | <0.0001 | |||
| Model 2: adjusted for metabolic covariates* | 1.0 | 1.13 (0.9–1.40) | 1.06 (0.84–1.35) | 1.38 (1.10–1.73)‖ | 0.0071 | |||
| Model 3: adjusted for lifestyle covariates† | 1.0 | 1.20 (0.97–1.48) | 1.09 (0.86–1.38) | 1.51 (1.21–1.89)‖ | 0.0005 | |||
| Model 4: adjusted for lifestyle covariates and BMI‡ | 1.0 | 1.16 (0.94–1.43) | 1.02 (0.81–1.30) | 1.28 (1.02–1.60)‖ | 0.06 | |||
| Model 5: adjusted for metabolic and lifestyle covariates§ | 1.0 | 1.12 (0.90–1.39) | 1.03 (0.81–1.31) | 1.31 (1.04–1.64)‖ | 0.04 | |||
Model 2: adjusted for age, race, ARIC center, education, sex, fasting insulin, fasting glucose, log triglycerides, HDL cholesterol, BMI, waist-to-hip ratio, and systolic blood pressure.
Model 3: adjusted for age, race, ARIC center, sex, education, physical activity, total caloric intake, and smoking status.
Model 4: adjusted for age, race, ARIC center, sex, education, physical activity, total caloric intake, smoking status, BMI, and waist-to-hip ratio.
Model 5: adjusted for age, race, ARIC center, education, sex, fasting insulin, fasting glucose, log triglycerides, HDL cholesterol, BMI, waist-to-hip ratio, systolic blood pressure, physical activity, total caloric intake, and smoking status.
P < 0.05.