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Table 2—

Cox proportional hazards models with baseline risk factors and incident CHD, age, and diabetes duration adjusted

Standardized hazard ratios (95% CI)
TotalMenWomen
n 2,329 1,202 1,127 
Age (years)* 1.60 (1.30–1.96) 1.55 (1.15–2.09) 1.67 (1.26–2.21) 
Diabetes duration (years)* 1.16 (0.95–1.40) 1.12 (0.85–1.49) 1.16 (0.89–1.52) 
GHb (%) 1.20 (1.02–1.41)§ 1.34 (1.06–1.68) 1.07 (0.85–1.35) 
Waist circumference (cm) 1.07 (0.92–1.26) 1.19 (0.94–1.52) 1.13 (0.92–1.39) 
WHR 1.15 (0.99–1.33) (P = 0.06) 1.32 (1.08–1.62) 1.16 (0.97–1.39) (P = 0.11) 
BMI (kg/m21.05 (0.90–1.23) 1.17 (0.92–1.48) 1.00 (0.81–1.24) 
Systolic BP (mmHg) 1.17 (1.01–1.36)§ 1.11 (0.88–1.39) 1.26 (1.03–1.54)§ 
Diastolic BP (mmHg) 0.98 (0.84–1.14) 0.90 (0.71–1.14) 1.08 (0.88–1.34) 
Cholesterol (mg/dl) 1.04 (0.88–1.22) 1.04 (0.81–1.33) 1.02 (0.82–1.26) 
LDL cholesterol (mg/dl) 1.05 (0.87–1.26) 1.12 (0.83–1.52) 1.00 (0.79–1.26) 
HDL cholesterol (mg/dl) 0.82 (0.70–0.97)§ 0.75 (0.58–0.97)§ 0.82 (0.66–1.02) (P = 0.08) 
Non-HDL cholesterol (mg/dl) 1.11 (0.96–1.30) (P = 0.17) 1.14 (0.90–1.43) 1.09 (0.89–1.34) 
FTG (mg/dl) 1.27 (1.08–1.50) 1.26 (0.96–1.64) (P = 0.10) 1.36 (1.10–1.69) 
Current smoking versus nonsmoking 1.30 (0.93–1.83) (P = 0.13) 1.62 (1.004–2.62)§ 1.08 (0.66–1.78) 
Exsmoking versus nonsmoking 0.70 (0.46–1.09) (P = 0.11) 0.70 (0.39–1.28) 0.78 (0.40–1.52) 
Retinopathy 1.68 (1.09–2.60)§ 1.42 (0.77–2.62) 2.02 (1.07–3.82)§ 
Neuropathy 1.34 (0.95–1.89) 1.77 (1.07–2.95)§ 1.07 (0.67–1.72) 
Autonomic neuropathy 1.41 (1.00–2.00) (P = 0.05) 1.79 (1.08–2.97)§ 1.15 (0.71–1.86) 
Microalbuminuria 1.65 (1.16–2.37) 1.57 (0.91–2.70) (P = 0.10) 1.87 (1.16–3.02) 
Macroalbuminuria 2.74 (1.79–4.19) 3.53 (1.97–6.33) 2.38 (1.24–4.57) 
AER (μg/min) 1.50 (1.32–1.70) 1.68 (1.39–2.02) 1.43 (1.20–1.71) 
Hypertension (yes versus no) 1.31 (0.91–1.86) (P = 0.14) 1.30 (0.77–2.18) 1.35 (0.83–2.19) 
Standardized hazard ratios (95% CI)
TotalMenWomen
n 2,329 1,202 1,127 
Age (years)* 1.60 (1.30–1.96) 1.55 (1.15–2.09) 1.67 (1.26–2.21) 
Diabetes duration (years)* 1.16 (0.95–1.40) 1.12 (0.85–1.49) 1.16 (0.89–1.52) 
GHb (%) 1.20 (1.02–1.41)§ 1.34 (1.06–1.68) 1.07 (0.85–1.35) 
Waist circumference (cm) 1.07 (0.92–1.26) 1.19 (0.94–1.52) 1.13 (0.92–1.39) 
WHR 1.15 (0.99–1.33) (P = 0.06) 1.32 (1.08–1.62) 1.16 (0.97–1.39) (P = 0.11) 
BMI (kg/m21.05 (0.90–1.23) 1.17 (0.92–1.48) 1.00 (0.81–1.24) 
Systolic BP (mmHg) 1.17 (1.01–1.36)§ 1.11 (0.88–1.39) 1.26 (1.03–1.54)§ 
Diastolic BP (mmHg) 0.98 (0.84–1.14) 0.90 (0.71–1.14) 1.08 (0.88–1.34) 
Cholesterol (mg/dl) 1.04 (0.88–1.22) 1.04 (0.81–1.33) 1.02 (0.82–1.26) 
LDL cholesterol (mg/dl) 1.05 (0.87–1.26) 1.12 (0.83–1.52) 1.00 (0.79–1.26) 
HDL cholesterol (mg/dl) 0.82 (0.70–0.97)§ 0.75 (0.58–0.97)§ 0.82 (0.66–1.02) (P = 0.08) 
Non-HDL cholesterol (mg/dl) 1.11 (0.96–1.30) (P = 0.17) 1.14 (0.90–1.43) 1.09 (0.89–1.34) 
FTG (mg/dl) 1.27 (1.08–1.50) 1.26 (0.96–1.64) (P = 0.10) 1.36 (1.10–1.69) 
Current smoking versus nonsmoking 1.30 (0.93–1.83) (P = 0.13) 1.62 (1.004–2.62)§ 1.08 (0.66–1.78) 
Exsmoking versus nonsmoking 0.70 (0.46–1.09) (P = 0.11) 0.70 (0.39–1.28) 0.78 (0.40–1.52) 
Retinopathy 1.68 (1.09–2.60)§ 1.42 (0.77–2.62) 2.02 (1.07–3.82)§ 
Neuropathy 1.34 (0.95–1.89) 1.77 (1.07–2.95)§ 1.07 (0.67–1.72) 
Autonomic neuropathy 1.41 (1.00–2.00) (P = 0.05) 1.79 (1.08–2.97)§ 1.15 (0.71–1.86) 
Microalbuminuria 1.65 (1.16–2.37) 1.57 (0.91–2.70) (P = 0.10) 1.87 (1.16–3.02) 
Macroalbuminuria 2.74 (1.79–4.19) 3.53 (1.97–6.33) 2.38 (1.24–4.57) 
AER (μg/min) 1.50 (1.32–1.70) 1.68 (1.39–2.02) 1.43 (1.20–1.71) 
Hypertension (yes versus no) 1.31 (0.91–1.86) (P = 0.14) 1.30 (0.77–2.18) 1.35 (0.83–2.19) 
*

Age adjusted for diabetes duration and vice versa for diabetes duration.

Log transformed;

P ≤ 0.0001;

§

P ≤ 0.05;

P ≤ 0.01;

P ≤ 0.001. Adjustment for center does not change these results. Standardized hazards ratios (Exp[β × SD]).

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