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TABLE 3

Adjusted RR for dementia of type 2 diabetes defined by different criteria

Elevated 2-h only*Incident diabetesADA definitionPrevalent diabetes§
Total dementia 1.1 (0.5–2.1) 1.4 (0.8–2.4) 1.6 (1.1–2.4) 1.6 (0.97–2.5) 
VsD 0.9 (0.2–4.1) 2.3 (0.8–6.2) 2.9 (1.3–6.5) 2.3 (0.9–5.8) 
AD 1.2 (0.5–2.9) 1.4 (0.7–2.9) 1.9 (1.1–3.2) 2.0 (1.1–3.6) 
AD without CVD 0.8 (0.2–2.8) 0.8 (0.3–2.3) 1.8 (0.9–3.5) 2.2 (1.1–4.2) 
Elevated 2-h only*Incident diabetesADA definitionPrevalent diabetes§
Total dementia 1.1 (0.5–2.1) 1.4 (0.8–2.4) 1.6 (1.1–2.4) 1.6 (0.97–2.5) 
VsD 0.9 (0.2–4.1) 2.3 (0.8–6.2) 2.9 (1.3–6.5) 2.3 (0.9–5.8) 
AD 1.2 (0.5–2.9) 1.4 (0.7–2.9) 1.9 (1.1–3.2) 2.0 (1.1–3.6) 
AD without CVD 0.8 (0.2–2.8) 0.8 (0.3–2.3) 1.8 (0.9–3.5) 2.2 (1.1–4.2) 

Data are RR (95% CI). Subjects without diabetes were adopted as the reference group. Analyses were adjusted for age, education, ε4 status, diabetes medication, midlife systolic blood pressure, cholesterol, BMI, ABI, and stroke. AD definition includes subjects with concomitant CVD contributing to dementia.

*

Subjects with normal fasting glucose but with 2-h glucose ≥200 mg/dl;

subjects with no reported diabetes but with fasting glucose ≥126 mg/dl or 2-h glucose ≥200 mg/dl;

American Diabetes Association (ADA) suggestion for epidemiological studies on diabetes includes subjects with reported diabetes or fasting glucose concentration ≥126 mg/dl;

§

subjects with self-reported diabetes.

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