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TABLE 5

Regression analysis of diabetes and APOE ε4 status on infarcts, NP, NFT, and CAA

Diabetes onlyAPOE ε4 onlyDiabetes/APOE ε4
Lacune* 1.0 (0.6–1.8) 0.9 (0.4–1.9) 1.5 (0.8–3.5) 
Large infarct* 1.8 (1.1–3.0) 1.6 (0.7–3.6) 1.2 (0.5–3.2) 
NP (cortex)* 0.8 (0.5–1.4) 1.1 (0.6–2.3) 1.5 (0.7–3.1) 
NP (hippocampus)* 1.2 (0.5–2.3) 2.0 (0.6–6.6) 3.0 (1.2–7.6) 
NFT (cortex) 1.0 (0.6–2.4) 2.9 (1.1–7.8) 3.5 (1.6–7.5) 
NFT (hippocampus)* 1.0 (0.6–1.4) 1.7 (1.1–2.8) 2.4 (1.5–3.7) 
CAA 0.6 (0.3–1.2) 3.6 (1.0–10.6) 6.6 (1.5–29.6) 
Diabetes onlyAPOE ε4 onlyDiabetes/APOE ε4
Lacune* 1.0 (0.6–1.8) 0.9 (0.4–1.9) 1.5 (0.8–3.5) 
Large infarct* 1.8 (1.1–3.0) 1.6 (0.7–3.6) 1.2 (0.5–3.2) 
NP (cortex)* 0.8 (0.5–1.4) 1.1 (0.6–2.3) 1.5 (0.7–3.1) 
NP (hippocampus)* 1.2 (0.5–2.3) 2.0 (0.6–6.6) 3.0 (1.2–7.6) 
NFT (cortex) 1.0 (0.6–2.4) 2.9 (1.1–7.8) 3.5 (1.6–7.5) 
NFT (hippocampus)* 1.0 (0.6–1.4) 1.7 (1.1–2.8) 2.4 (1.5–3.7) 
CAA 0.6 (0.3–1.2) 3.6 (1.0–10.6) 6.6 (1.5–29.6) 

Data are IRR (95% CI) or RR (95% CI). Participants with no diabetes and no ε4 served as the reference group to calculate RR and 95% CI. Analyses were adjusted for age at exam 4, interval between exam 4 and death, education, smoking status, alcohol, midlife cholesterol and systolic blood pressure, BMI, and ABI.

*

Poisson regression, IRR,

logistic regression, RR.

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