Influence of background retinopathy and age on brain volumes (adjusted for intracranial volume by MANCOVA)
| Brain volume (cm3) . | No retinopathy . | Retinopathy . | Effect of retinopathy . | Effect of age . |
|---|---|---|---|---|
| Whole brain | 1,261 (1,242–1,281) | 1,250 (1,225–1,275) | P = 0.76, Eta2 <0.01 | P = 0.04, Eta2 = 0.07 |
| Lateral ventricles | 22.3 (20–25) | 17.9 (15–21) | P = 0.14, Eta2 = 0.04 | P = 0.50, Eta2 <0.01 |
| Right temporal lobe | 77.4 (75–79) | 74.6 (72–77) | P = 0.08, Eta2 = 0.05 | P = 0.80, Eta2 <0.01 |
| Left temporal lobe | 72.4 (71–74) | 72.5 (70–75) | P = 0.44, Eta2 <0.01 | P = 0.99, Eta2 <0.01 |
| Right amygdala-hippocampal complex | 4.5 (4.3–4.6) | 4.3 (4.1–4.5) | P = 0.23, Eta2 = 0.02 | P = 0.005, Eta2 = 0.12 |
| Left amygdala-hippocampal complex | 4.4 (4.2–4.6) | 4.3 (4.0–4.5) | P = 0.39, Eta2 = 0.01 | P = 0.006, Eta2 = 0.12 |
| Brain volume (cm3) . | No retinopathy . | Retinopathy . | Effect of retinopathy . | Effect of age . |
|---|---|---|---|---|
| Whole brain | 1,261 (1,242–1,281) | 1,250 (1,225–1,275) | P = 0.76, Eta2 <0.01 | P = 0.04, Eta2 = 0.07 |
| Lateral ventricles | 22.3 (20–25) | 17.9 (15–21) | P = 0.14, Eta2 = 0.04 | P = 0.50, Eta2 <0.01 |
| Right temporal lobe | 77.4 (75–79) | 74.6 (72–77) | P = 0.08, Eta2 = 0.05 | P = 0.80, Eta2 <0.01 |
| Left temporal lobe | 72.4 (71–74) | 72.5 (70–75) | P = 0.44, Eta2 <0.01 | P = 0.99, Eta2 <0.01 |
| Right amygdala-hippocampal complex | 4.5 (4.3–4.6) | 4.3 (4.1–4.5) | P = 0.23, Eta2 = 0.02 | P = 0.005, Eta2 = 0.12 |
| Left amygdala-hippocampal complex | 4.4 (4.2–4.6) | 4.3 (4.0–4.5) | P = 0.39, Eta2 = 0.01 | P = 0.006, Eta2 = 0.12 |
Data are mean volume (95% CI) unless otherwise indicated.