TABLE 3

Influence of −23Hph1 on birth weight

Number of subjects (nuclear families)Number informativeGenotypes
ModelEffectβP
AAATTT
192 (92) 192 133 54 T-allele −140 0.046 
192 (92) 87 42 42 Between family −61 0.67 
      Within-family −190 0.03 
187 (92)* 82 133 49 Between-family −39 0.73 
      Paternal (wpa−250 0.05 
      Maternal (wma−111 0.43 
Number of subjects (nuclear families)Number informativeGenotypes
ModelEffectβP
AAATTT
192 (92) 192 133 54 T-allele −140 0.046 
192 (92) 87 42 42 Between family −61 0.67 
      Within-family −190 0.03 
187 (92)* 82 133 49 Between-family −39 0.73 
      Paternal (wpa−250 0.05 
      Maternal (wma−111 0.43 

Effect of simple association of genotype (model 1) and models examining linkage disequilibrium without (model 2) or with (model 3) influences of parent of origin of T-allele. The joint hypothesis of linkage and association is examined by “within family” effects. β is given as effect of each additional T-allele (model 1 and between-family effects in models 2 and 3) or per additional T-allele above that expected, given parental genotype (within family effects, models 2 and 3). All models include random effect of nuclear family. Birth weight is adjusted for sex, gestational age at birth, birth year, and maternal diabetes.

*

Number is reduced as inheritance of offspring T-allele in triple heterozygote trios (mother, father, and child) cannot be defined.

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