Genotype distribution and allele frequencies of the Pro12Ala and exon 6 C→T polymorphisms of PPARγ according to glucose tolerance status
| . | Type 2 diabetes . | IGT . | NGT . | P . |
|---|---|---|---|---|
| n | 32 | 54 | 188 | |
| Pro12Ala | ||||
| Pro/Pro | 30 (94) | 45 (83) | 141 (75) | |
| Pro/Ala | 2 (6) | 8 (15) | 41 (22) | 0.07 (0.07) |
| Ala/Ala | 0 (0) | 1 (2) | 6 (3) | |
| Allele frequency | 3.1 (−1.1 to 7.4) | 9.3 (3.8–14.7) | 15.2 (11.8–18.6) | 0.01 (0.01) |
| Exon 6 | ||||
| C/C | 26 (81) | 45 (83) | 148 (79) | |
| C/T | 6 (19) | 8 (15) | 38 (20) | 1.0 (0.5) |
| T/T | 0 (0) | 1 (2) | 1 (1) | |
| Allele frequency | 9.4 (2.2–16.5) | 9.3 (3.8–14.7) | 10.7 (7.6–13.8) | 1.0 (0.7) |
| . | Type 2 diabetes . | IGT . | NGT . | P . |
|---|---|---|---|---|
| n | 32 | 54 | 188 | |
| Pro12Ala | ||||
| Pro/Pro | 30 (94) | 45 (83) | 141 (75) | |
| Pro/Ala | 2 (6) | 8 (15) | 41 (22) | 0.07 (0.07) |
| Ala/Ala | 0 (0) | 1 (2) | 6 (3) | |
| Allele frequency | 3.1 (−1.1 to 7.4) | 9.3 (3.8–14.7) | 15.2 (11.8–18.6) | 0.01 (0.01) |
| Exon 6 | ||||
| C/C | 26 (81) | 45 (83) | 148 (79) | |
| C/T | 6 (19) | 8 (15) | 38 (20) | 1.0 (0.5) |
| T/T | 0 (0) | 1 (2) | 1 (1) | |
| Allele frequency | 9.4 (2.2–16.5) | 9.3 (3.8–14.7) | 10.7 (7.6–13.8) | 1.0 (0.7) |
Only one (random) twin from each pair and single twins are included in the analysis. P indicates the P values in the comparison of type 2 diabetes versus NGT and abnormal glucose tolerance (type 2 diabetes plus IGT) versus NGT, respectively. Genotype distribution is presented as n (%); allele frequency is presented as frequency (95% CI).