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TABLE 1

Frequency of induced diabetes in LEW0.1WR1 rats

Treatment typeGroupPoly I:CVirusnn (%) diabetic
Culture medium alone No None 16 0 (0) 
Single viral inoculations* No KRV alone 3 (38) 
 No RCMV alone 38 14 (37) 
 No Coxsackie B4 alone§ 18 0 (0) 
 No Vaccinia alone 14 1 (7) 
 No H-1 alone 20 0 (0) 
 Yes None 18 0 (0) 
 No RCMV + KRV 45 34 (76) 
Simultaneous viral inoculations No RCMV + CoxB4 1 (13) 
10 Yes KRV 6 (100) 
Sequential treatments** 11 Yes RCMV 29 3 (10) 
12 Yes Coxsackie B4 18 3 (17) 
13 Yes Vaccinia 10 4 (40) 
14 Yes H-1 0 (0) 
Treatment typeGroupPoly I:CVirusnn (%) diabetic
Culture medium alone No None 16 0 (0) 
Single viral inoculations* No KRV alone 3 (38) 
 No RCMV alone 38 14 (37) 
 No Coxsackie B4 alone§ 18 0 (0) 
 No Vaccinia alone 14 1 (7) 
 No H-1 alone 20 0 (0) 
 Yes None 18 0 (0) 
 No RCMV + KRV 45 34 (76) 
Simultaneous viral inoculations No RCMV + CoxB4 1 (13) 
10 Yes KRV 6 (100) 
Sequential treatments** 11 Yes RCMV 29 3 (10) 
12 Yes Coxsackie B4 18 3 (17) 
13 Yes Vaccinia 10 4 (40) 
14 Yes H-1 0 (0) 

Twenty- to 25-day-old male and female LEW0.1WR1 rats were inoculated intraperitoneally with the indicated viral agents with or without pretreatment with poly I:C as described in research design and methods. Doses were as follows: KRV, 107 PFU; H-1, 107 PFU; CoxB4, 108 PFU; VV, 106 PFU; or RCMV, 104 PFU.

*Overall χ2 for single virus inoculation category = 25.48, df = 5, P = 0.001.

†Group 3 vs. group 8, Fisher exact statistic, P = 0.0007.

‡Group 3 vs. group 11: Fisher exact statistic, P = 0.02.

§Group 4 vs. group 12, P = NS.

‖Group 5 vs. group 13, Fisher exact statistic, P = NS.

¶Group 8 vs. group 9, Fisher exact statistic, P = 0.001.

**Overall χ2 for sequential treatments category = 25.58, df = 3, P < 0.001. In all experiments in which diabetes occurred, both male and female rats were affected. In groups 3 and 8 in which there were larger numbers of diabetic animals, both sexes were affected in approximately equal proportions.

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