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TABLE 2

Frequency of induced diabetes in LEW.1WR1 rats

GroupMaternal inoculumProgeny inoculumnn (%) diabetic
1* None RCMV 13 8 (62) 
RCMV RCMV 26 0 (0) 
3 None KRV 3 (38) 
RCMV KRV 13 8 (62) 
5 None RCMV + KRV 10 10 (100) 
RCMV + KRV RCMV + KRV 11 0 (0) 
GroupMaternal inoculumProgeny inoculumnn (%) diabetic
1* None RCMV 13 8 (62) 
RCMV RCMV 26 0 (0) 
3 None KRV 3 (38) 
RCMV KRV 13 8 (62) 
5 None RCMV + KRV 10 10 (100) 
RCMV + KRV RCMV + KRV 11 0 (0) 

Twenty- to 25-day-old female LEW.1WR1 rats were either left untreated or were inoculated intraperitoneally with RCMV alone or RCMV and KRV simultaneously as described in research design and methods. Females that did not become diabetic were mated to naïve male LEW.1WR1 rats. The resulting pups were inoculated with the indicated viruses at 20–25 days of age and followed for 40 days or until onset of diabetes. The doses of administered at each stage of the experiment were 107 PFU for KRV and 104 PFU for RCMV.

*Fisher exact statistic, P < 0.0001 vs. group 2.

†Fisher exact statistic, P = 0.39 vs. group 4.

‡Fisher exact statistic, P < 0.0001 vs. group 6.

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