American Diabetes Association

TABLE 2

Frequency of induced diabetes in LEW.1WR1 rats

Group	Maternal inoculum	Progeny inoculum	n	n (%) diabetic
1*	None	RCMV	13	8 (62)
2	RCMV	RCMV	26	0 (0)
3†	None	KRV	8	3 (38)
4	RCMV	KRV	13	8 (62)
5‡	None	RCMV + KRV	10	10 (100)
6	RCMV + KRV	RCMV + KRV	11	0 (0)

Group	Maternal inoculum	Progeny inoculum	n	n (%) diabetic
1*	None	RCMV	13	8 (62)
2	RCMV	RCMV	26	0 (0)
3†	None	KRV	8	3 (38)
4	RCMV	KRV	13	8 (62)
5‡	None	RCMV + KRV	10	10 (100)
6	RCMV + KRV	RCMV + KRV	11	0 (0)

Twenty- to 25-day-old female LEW.1WR1 rats were either left untreated or were inoculated intraperitoneally with RCMV alone or RCMV and KRV simultaneously as described in research design and methods. Females that did not become diabetic were mated to naïve male LEW.1WR1 rats. The resulting pups were inoculated with the indicated viruses at 20–25 days of age and followed for 40 days or until onset of diabetes. The doses of administered at each stage of the experiment were 10⁷ PFU for KRV and 10⁴ PFU for RCMV.

*Fisher exact statistic, P < 0.0001 vs. group 2.

†Fisher exact statistic, P = 0.39 vs. group 4.

‡Fisher exact statistic, P < 0.0001 vs. group 6.

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