Skip to Main Content
TABLE 1

Clinical characteristics of the individual study samples

Hoorn*Utrecht*
NTR Twins*
IGTNGTIGTNGTIGT
n 137 64 12 116 
Sex (male/female) 64/73 15/49 4/8 58/58 0/7 
Age (years) 60.5 ± 8.6 45.9 ± 6.4 49.5 ± 7.7 31.5 ± 6.5 31.2 ± 3.2 
BMI (kg/m228.1 ± 4.0 25.8 ± 3.8 26.7 ± 4.1 24.2 ± 3.5 24.5 ± 3.3 
Fasting plasma glucose (mmol/l) 6.3 ± 0.7 4.6 ± 0.4 5.1 ± 0.4 4.6 ± 0.4 4.6 ± 0.6 
2-h plasma glucose (mmol/l) 8.8 ± 1.7 5.1 ± 1.0 8.5 ± 1.2 5.2 ± 1.1 8.1 ± 0.3 
Fasting plasma insulin (pmol/l) 62 (46–91) 30 (24–42) 66 (42–78) 34 (27–51) 39 (29–60) 
First-phase insulin response (pmol/l) 587 (378–895) 885 (644–1,217) 678 (461–909) 814 (589–1,162) 795 (693–1,210) 
Second-phase insulin response (pmol/l) 255 (176–354) 260 (191–365) 251 (186–307) 218 (162–358) 217 (210–434) 
ISI (μmol · min−1 · kg−1 · pmol−1 · l−10.108 (0.068–0.164) 0.190 (0.127–0.282) 0.111 (0.082–0.256) 0.227 (0.152–0.323) 0.123 (0.109–0.183) 
DI (μmol · min−1 · kg−165 (42–92) 172 (103–238) 72 (55–128) 180 (140–234) 138 (82–151) 
GLP-1–stimulated insulin release (pmol/l) NA NA NA 1,225 (734–2,587) 848 (577–1,239) 
Arginine-stimulated insulin release (pmol/l) NA NA NA 2,188 (1,526–2,973) 1,673 (1,438–1,908) 
Hoorn*Utrecht*
NTR Twins*
IGTNGTIGTNGTIGT
n 137 64 12 116 
Sex (male/female) 64/73 15/49 4/8 58/58 0/7 
Age (years) 60.5 ± 8.6 45.9 ± 6.4 49.5 ± 7.7 31.5 ± 6.5 31.2 ± 3.2 
BMI (kg/m228.1 ± 4.0 25.8 ± 3.8 26.7 ± 4.1 24.2 ± 3.5 24.5 ± 3.3 
Fasting plasma glucose (mmol/l) 6.3 ± 0.7 4.6 ± 0.4 5.1 ± 0.4 4.6 ± 0.4 4.6 ± 0.6 
2-h plasma glucose (mmol/l) 8.8 ± 1.7 5.1 ± 1.0 8.5 ± 1.2 5.2 ± 1.1 8.1 ± 0.3 
Fasting plasma insulin (pmol/l) 62 (46–91) 30 (24–42) 66 (42–78) 34 (27–51) 39 (29–60) 
First-phase insulin response (pmol/l) 587 (378–895) 885 (644–1,217) 678 (461–909) 814 (589–1,162) 795 (693–1,210) 
Second-phase insulin response (pmol/l) 255 (176–354) 260 (191–365) 251 (186–307) 218 (162–358) 217 (210–434) 
ISI (μmol · min−1 · kg−1 · pmol−1 · l−10.108 (0.068–0.164) 0.190 (0.127–0.282) 0.111 (0.082–0.256) 0.227 (0.152–0.323) 0.123 (0.109–0.183) 
DI (μmol · min−1 · kg−165 (42–92) 172 (103–238) 72 (55–128) 180 (140–234) 138 (82–151) 
GLP-1–stimulated insulin release (pmol/l) NA NA NA 1,225 (734–2,587) 848 (577–1,239) 
Arginine-stimulated insulin release (pmol/l) NA NA NA 2,188 (1,526–2,973) 1,673 (1,438–1,908) 

Data are means ± SD, median (interquartile range), or n.

*Original population from which the cohort originated (26,28–30). NA, not available.

Close Modal

or Create an Account

Close Modal
Close Modal