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Table 3—

Development of different clinical parameters in patients with type 1 diabetes and celiac disease measured before and after 6, 12, 18, and 24 months of starting a GFD

nDuration of the GFD
Baseline6 months12 months18 months24 monthsP value
Weight SDS 27 −0.12 0.11 0.25* 0.30* 0.35* 0.002 
Height SDS 27 −0.46 −0.37 −0.31 −0.24 −0.26 0.073 
A1C (%) 28 8.6 9.0 8.8 8.7 8.4 0.300 
Hemoglobin (mmol/l) 25 7.6 8.4* 8.3* 8.4* 8.3* 0.001 
Mean corpuscular volume (fl) 25 81.6 83.0 83.8 83.5 84.4* 0.020 
Ferritin (μg/l) 26 26.0 31.1 39.8* 44* 37.9* 0.012 
Folate (nmol/l) 24 489 606* 637* 639* 581 0.076 
Cobalamin (pmol/l) 25 387 416 415 395 379 0.872 
Calcium (mmol/l) 23 1.24 1.26* 1.26* 1.26* 1.26* 0.044 
ALAT (units/l) 26 24.9 27.2 21.0 19.7* 20.6 0.062 
nDuration of the GFD
Baseline6 months12 months18 months24 monthsP value
Weight SDS 27 −0.12 0.11 0.25* 0.30* 0.35* 0.002 
Height SDS 27 −0.46 −0.37 −0.31 −0.24 −0.26 0.073 
A1C (%) 28 8.6 9.0 8.8 8.7 8.4 0.300 
Hemoglobin (mmol/l) 25 7.6 8.4* 8.3* 8.4* 8.3* 0.001 
Mean corpuscular volume (fl) 25 81.6 83.0 83.8 83.5 84.4* 0.020 
Ferritin (μg/l) 26 26.0 31.1 39.8* 44* 37.9* 0.012 
Folate (nmol/l) 24 489 606* 637* 639* 581 0.076 
Cobalamin (pmol/l) 25 387 416 415 395 379 0.872 
Calcium (mmol/l) 23 1.24 1.26* 1.26* 1.26* 1.26* 0.044 
ALAT (units/l) 26 24.9 27.2 21.0 19.7* 20.6 0.062 

Data are means of the group. At 24 months follow-up, the corresponding P values are also presented. Only a few follow-up data were available from patients with celiac disease diagnosed before this study. The increase in hemoglobin was not caused by the increase in hemoglobin seen in male puberty. Paired comparisons were performed by Wilcoxon signed-ranked test.

*

Significant changes from baseline.

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