American Diabetes Association

Table 1—

Clinical characteristics in the intention-to-treat population

	Placebo	ALA600	ALA1200	ALA1800
n	43	45	47	46
Age (years)	57 ± 11	56 ± 12	59 ± 12	59 ± 9
Sex (% male)	35	44	40	41
BMI (kg/m²)	29.1 ± 4.4	28.7 ± 3.9	30.9 ± 4.5	28.4 ± 4.8
Systolic blood pressure (mmHg)	134 ± 19	134 ± 16	141 ± 17	135 ± 10
Systolic blood pressure (mmHg)	81 ± 9	80 ± 10	83 ± 7	82 ± 9
Heart rate (bpm)	73 ± 9	74 ± 12	73 ± 10	72 ± 8
Diabetes type (% type 2)	84	82	83	85
Duration of diabetes (years)	14 ± 10	13 ± 8	14 ± 10	15 ± 11
Insulin treatment (%)	42	60	53	57
Treatment with oral antidiabetic agents (%)	74	67	64	50
A1C (%)	7.53 ± 1.18	7.58 ± 1.09	7.85 ± 1.31	7.81 ± 1.14
Smokers (%)^*	0	11	11	9
Hypertension (%)	61	69	68	72
Polyneuropathy stage (% stage 2a)	93	82	89	98
Duration of neuropathy (years)	4.9 ± 3.2	4.8 ± 3.9	5.0 ± 3.8	4.9 ± 4.0
Retinopathy (%)	51	67	75	74
Nephropathy (%)	26	20	17	22

	Placebo	ALA600	ALA1200	ALA1800
n	43	45	47	46
Age (years)	57 ± 11	56 ± 12	59 ± 12	59 ± 9
Sex (% male)	35	44	40	41
BMI (kg/m²)	29.1 ± 4.4	28.7 ± 3.9	30.9 ± 4.5	28.4 ± 4.8
Systolic blood pressure (mmHg)	134 ± 19	134 ± 16	141 ± 17	135 ± 10
Systolic blood pressure (mmHg)	81 ± 9	80 ± 10	83 ± 7	82 ± 9
Heart rate (bpm)	73 ± 9	74 ± 12	73 ± 10	72 ± 8
Diabetes type (% type 2)	84	82	83	85
Duration of diabetes (years)	14 ± 10	13 ± 8	14 ± 10	15 ± 11
Insulin treatment (%)	42	60	53	57
Treatment with oral antidiabetic agents (%)	74	67	64	50
A1C (%)	7.53 ± 1.18	7.58 ± 1.09	7.85 ± 1.31	7.81 ± 1.14
Smokers (%)^*	0	11	11	9
Hypertension (%)	61	69	68	72
Polyneuropathy stage (% stage 2a)	93	82	89	98
Duration of neuropathy (years)	4.9 ± 3.2	4.8 ± 3.9	5.0 ± 3.8	4.9 ± 4.0
Retinopathy (%)	51	67	75	74
Nephropathy (%)	26	20	17	22

Data means ± SD unless otherwise indicated.

*

Smoker within the last 2 years.