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Table 4

HRs for primary and secondary cardiovascular disease outcomes based on 1-year and 4-year change in physical activity (N = 1,978)

CVD outcomes1-year change in physical activity per increase of 100 MET-min/week
Change in accelerometery-measured total MVPAChange in accelerometry-measured MVPA in bouts ≥10 minChange in self-reported measured physical activity
Events (N)*HR (95% CI)**Events (N)*HR (95% CI)**Events (N)*HR (95% CI)**
Primary outcome# 247 (1,552) 1.002 (0.992, 1.013) 247 (1,552) 1.001 (0.985, 1.017) 277 (1,817) 1.004 (0.989, 1.019) 
Secondary outcome 1$ 174 (1,555) 0.991 (0.975, 1.007) 174 (1,555) 0.989 (0.966, 1.013) 197 (1,821) 1.000 (0.981, 1.019) 
Secondary outcome 2 318 (1,552) 0.999 (0.989, 1.009) 318 (1,552) 0.997 (0.982, 1.012) 360 (1,817) 1.000 (0.987, 1.014) 
Secondary outcome 3& 375 (1,548) 0.994 (0.983, 1.004) 375 (1,548) 0.990 (0.974, 1.006) 425 (1,811) 0.998 (0.986, 1.011) 
 4-year change in physical activity per increase of 100 MET-min/week 
 Primary outcome# 164 (1,610) 0.973 (0.953, 0.993) 164 (1,610) 0.946 (0.909, 0.984) 173 (1,685) 1.002 (0.982, 1.022) 
Secondary outcome 1$ 127 (1,655) 0.949 (0.923, 0.976) 127 (1,655) 0.895 (0.841, 0.953) 134 (1,730) 0.985 (0.960, 1.011) 
Secondary outcome 2 225 (1,610) 0.967 (0.950, 0.985) 225 (1,610) 0.940 (0.908, 0.973) 236 (1,685) 0.989 (0.971, 1.008) 
Secondary outcome 3& 259 (1,577) 0.974 (0.958, 0.990) 259 (1,577) 0.946 (0.917, 0.976) 271 (1,650) 0.993 (0.977, 1.010) 
CVD outcomes1-year change in physical activity per increase of 100 MET-min/week
Change in accelerometery-measured total MVPAChange in accelerometry-measured MVPA in bouts ≥10 minChange in self-reported measured physical activity
Events (N)*HR (95% CI)**Events (N)*HR (95% CI)**Events (N)*HR (95% CI)**
Primary outcome# 247 (1,552) 1.002 (0.992, 1.013) 247 (1,552) 1.001 (0.985, 1.017) 277 (1,817) 1.004 (0.989, 1.019) 
Secondary outcome 1$ 174 (1,555) 0.991 (0.975, 1.007) 174 (1,555) 0.989 (0.966, 1.013) 197 (1,821) 1.000 (0.981, 1.019) 
Secondary outcome 2 318 (1,552) 0.999 (0.989, 1.009) 318 (1,552) 0.997 (0.982, 1.012) 360 (1,817) 1.000 (0.987, 1.014) 
Secondary outcome 3& 375 (1,548) 0.994 (0.983, 1.004) 375 (1,548) 0.990 (0.974, 1.006) 425 (1,811) 0.998 (0.986, 1.011) 
 4-year change in physical activity per increase of 100 MET-min/week 
 Primary outcome# 164 (1,610) 0.973 (0.953, 0.993) 164 (1,610) 0.946 (0.909, 0.984) 173 (1,685) 1.002 (0.982, 1.022) 
Secondary outcome 1$ 127 (1,655) 0.949 (0.923, 0.976) 127 (1,655) 0.895 (0.841, 0.953) 134 (1,730) 0.985 (0.960, 1.011) 
Secondary outcome 2 225 (1,610) 0.967 (0.950, 0.985) 225 (1,610) 0.940 (0.908, 0.973) 236 (1,685) 0.989 (0.971, 1.008) 
Secondary outcome 3& 259 (1,577) 0.974 (0.958, 0.990) 259 (1,577) 0.946 (0.917, 0.976) 271 (1,650) 0.993 (0.977, 1.010) 
*

Events for 1-year analyses occurred between year 1 and a maximum of 13.5 years of follow-up; events for 4-year analyses occurred between year 4 and a maximum of 13.5 years of follow-up.

**

Controlling for treatment group, age, baseline physical activity, sex, baseline history of CVD, duration of diabetes at baseline, using insulin or other diabetes medication, baseline weight, and change in weight.

#

First occurrence after study enrollment of nonfatal myocardial infarction or stroke, hospitalized angina, or CVD death.

$

CVD death, nonfatal myocardial infarction, or nonfatal stroke.

All-cause death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for angina.

&

All-cause death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for angina; hospitalization for congestive heart failure, coronary artery bypass graph, carotid endarterectomy, or peripheral vascular disease.

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