LCMV infects cells in the spleen but rarely infects cells in the pancreas of SOCS-1-Tg and non-Tg mice. Representative immunostaining of spleen (A and B) and pancreas (C and D) from an uninfected (A and C) and an LCMV-infected (B and D) SOCS-1-Tg mouse. Organs were harvested from infected mice on day 7 p.i. The sections were cut from frozen organs and stained with an antibody to LCMV. Note the presence of LCMV-positive cells in the spleen (B) but not pancreas (D) of the infected mouse. Original magnifications were 40× (A and B) and 20× (C and D).