FIGURE 3
Contributing mechanisms to the panoply of effects of SGLT2 inhibitors. NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3; HIF-1, hypoxiainducible factor. Adapted from Rajasekeran H, Lytvyn Y, Cherney DZI. Kidney Int 2016;89:524–526 and Packer M. Am J Nephrol 2020;51:289–293.

Contributing mechanisms to the panoply of effects of SGLT2 inhibitors. NLRP3, NOD-, LRR-, and pyrin domain-containing protein 3; HIF-1, hypoxiainducible factor. Adapted from Rajasekeran H, Lytvyn Y, Cherney DZI. Kidney Int 2016;89:524–526 and Packer M. Am J Nephrol 2020;51:289–293.

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